急性热诱发疾病患者体内存在针对可诱导 Hsp71 的抗体。

T Wu, S Chen, C Xiao, C Wang, Q Pan, Z Wang, M Xie, Z Mao, Y Wu, R M Tanguay
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引用次数: 0

摘要

热休克或应激蛋白(Hsps)抗体在许多疾病中都有报道,这些抗体可能与疾病的发病机制有关,也可能对预后有帮助。热引起的疾病,如热痉挛、热衰竭或中暑,在炎热的工作或生活环境中很常见。关于热引起的疾病中是否存在针对Hsps的自身抗体及其可能的意义的研究仍然很少。我们使用重组人Hsps的免疫印迹技术,分析了一组42名在训练中出现急性热诱发疾病的年轻男性患者体内Hsp60、Hsp71、Hsp90alpha和Hsp90beta抗体的存在和滴度。我们还检测了第二组 57 名急性热诱发疾病患者体内 Hsp71 抗体的存在情况,并测量了 9 名急诊住院患者体内抗 Hsp71 抗体滴度的变化。在第一组在高温环境下运动的年轻人中,出现热诱发疾病症状的人体内的 Hsp71 和 Hsp90alpha 抗体的出现率(P < 0.05)明显高于匹配的未受影响的运动人群。此外,Hsp71 抗体的滴度在严重和轻度热诱发疾病组中都较高,滴度最高的是最严重的病例。第二组 57 名受极端高温影响的热病患者的结果与此类似。同样,热诱发症状较重的患者体内 Hsp71 抗体的发生率明显高于对照组,且严重患者组的抗 Hsp71 滴度较高。最后,在一项针对 9 名患者的研究中观察到,抗 Hsp71 滴度在严重高温症状恢复期间有所下降。这些结果表明,Hsps 抗体的测定可能有助于评估个人对生活和工作环境中异常压力的反应,并可作为一种生物标志物来评估他们对热引起的疾病的易感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Presence of antibody against the inducible Hsp71 in patients with acute heat-induced illness.

Antibodies against heat shock or stress proteins (Hsps) have been reported in a number of diseases in which they may be involved in the pathogenesis of the disease or may be of use for prognosis. Heat-induced diseases, such as heat cramps, heat exhaustion, or heat stroke, are frequent in hot working or living environments. There are still few investigations on the presence and possible significance of autoantibodies against Hsps in heat-induced illnesses. Using an immunoblotting technique with recombinant human Hsps, we analyzed the presence and titers of antibodies against Hsp60, Hsp71, and Hsp90alpha, and Hsp90beta in a group of 42 young male patients who presented with acute heat-induced illness during training. We also examined the presence of antibody against Hsp71 in a second group of 57 patients with acute heat-induced illness and measured the changes in titers of anti-Hsp71 antibodies in 9 patients hospitalized by emergency physicians. In the first group of young persons exercising in a hot environment, the occurrence of antibodies against Hsp71 and Hsp90alpha was significantly higher among individuals with symptoms of heat-induced illness (P < 0.05) than in the matched group of nonaffected exercising individuals. Moreover titers of antibody against Hsp71 were higher in individuals of the severe and mild heat-induced illness groups, the highest titer being found in the most severe cases. The results from the second group of 57 heat-affected patients exposed to extreme heat were similar. Again, patients with the more severe heat-induced symptoms showed a significantly higher incidence of antibodies to Hsp71 than controls and the titer of anti-Hsp71 was higher in the severely affected group. Finally, in a study of 9 patients, it was observed that the titer of anti-Hsp71 decreased during recovery from severe heat symptoms. These results suggest that measurement of antibodies to Hsps may be useful in assessing how individuals are responding to abnormal stress within their living and working environment and may be used as one biomarker to evaluate their susceptibility to heat-induced diseases.

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