电子束辐照对静电纺丝制备支架的影响

2015 International Conference on Biomedical Engineering and Computational Technologies (SIBIRCON) Pub Date : 2015-12-28 DOI:10.1109/SIBIRCON.2015.7361846

A. Stepanova, M. V. Korobeinikov, A. S. Yunoshev, P. Laktionov

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引用次数: 1

摘要

研究了电子束辐照对尼龙6、聚己内酯(PCL)和聚乳酸-羟基乙酸(PLGA)制备的电纺丝支架的刚度、稳定性和生物相容性的影响。结果表明，用电子束加速器ILA-6 (2.2 MeV, 400 mA 10 Hz，“放射化学技术有限公司”)产生的电子束照射基质可以潜在地用于基质的灭菌(25 kGy的剂量照射不会干扰所有研究基质的机械性能)。以100 kGy的剂量照射PCL产生的基质增加了材料的比例限制，并允许我们通过具有开放区域的模板照射移植物，从而将耐久区域引入血管移植物。正如Alamar Blue实验所显示的那样，电子束照射基质不会干扰基质在这些基质表面支持粘附和原代人内皮细胞活力的能力。

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Effect of electron-beam irradiation on electrospinning produced scaffolds

The influence of electron beam irradiation on the stiffness, stability and biocompatibility of electrospun scaffolds, produced from Nylon 6, polycaprolactone (PCL) and poly(DL-lactic-co-glicolic acid) (PLGA) was investigated. It was shown that irradiation of the matrices with an electron beam generated by the electron beam accelerator ILA-6 (2.2 MeV, 400 mA 10 Hz, “Radiochemical technologies Ltd”) can potentially be used for sterilization of the matrices (irradiation by a dose of 25 kGy does not interfere with the mechanical properties of all studied matrices). Irradiation of the matrices produced from PCL by a dose of 100 kGy increases the proportional limit of the material and allowed us to introduce durable regions into the vascular grafts by irradiating the graft through the template with open areas. Electron beam irradiation of the matrices does not interfere with the capacity of the matrices to support adhesion and viability of primary human endotheliocytes at the surfaces of these matrices, as it was shown using Alamar Blue assay.

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2015 International Conference on Biomedical Engineering and Computational Technologies (SIBIRCON)

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