{"title":"大鼠肝脏中游离核糖体与结合核糖体的代谢关系","authors":"Y Moule, G.Delhumeau De Ongay","doi":"10.1016/0926-6550(64)90175-6","DOIUrl":null,"url":null,"abstract":"<div><p>The interrelationships between the free and bound ribosomes of the hepatic cell in the regenerating rat liver have been studied by an examination of the metabolic relationships between RNA's of these two kinds of particles.</p><p>The kinetics of incorporation of [<sup>14</sup>C]orotic acid show no precursor-product relationship between the RNA's of free and bound ribosomes. This means that there is no systematic derivation of one kind of particle from the other. So, it is not obligatory for the life of a newly synthesized ribosome to proceed from that of a free state to that of a membrane-bound state, or inversely.</p><p>The results do not establish, however, that the two populations are independent. Indeed, the kinetics suggest the possibility of a constant exchange between them.</p><p>In addition, a precursor-product relationship has been found between nuclear RNA and ribosomal RNA. The different results are discussed.</p></div>","PeriodicalId":100173,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1964-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6550(64)90175-6","citationCount":"24","resultStr":"{\"title\":\"Relations métaboliques entre les ribosomes libres et liés du foie de rat\",\"authors\":\"Y Moule, G.Delhumeau De Ongay\",\"doi\":\"10.1016/0926-6550(64)90175-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The interrelationships between the free and bound ribosomes of the hepatic cell in the regenerating rat liver have been studied by an examination of the metabolic relationships between RNA's of these two kinds of particles.</p><p>The kinetics of incorporation of [<sup>14</sup>C]orotic acid show no precursor-product relationship between the RNA's of free and bound ribosomes. This means that there is no systematic derivation of one kind of particle from the other. So, it is not obligatory for the life of a newly synthesized ribosome to proceed from that of a free state to that of a membrane-bound state, or inversely.</p><p>The results do not establish, however, that the two populations are independent. Indeed, the kinetics suggest the possibility of a constant exchange between them.</p><p>In addition, a precursor-product relationship has been found between nuclear RNA and ribosomal RNA. The different results are discussed.</p></div>\",\"PeriodicalId\":100173,\"journal\":{\"name\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1964-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0926-6550(64)90175-6\",\"citationCount\":\"24\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0926655064901756\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0926655064901756","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Relations métaboliques entre les ribosomes libres et liés du foie de rat
The interrelationships between the free and bound ribosomes of the hepatic cell in the regenerating rat liver have been studied by an examination of the metabolic relationships between RNA's of these two kinds of particles.
The kinetics of incorporation of [14C]orotic acid show no precursor-product relationship between the RNA's of free and bound ribosomes. This means that there is no systematic derivation of one kind of particle from the other. So, it is not obligatory for the life of a newly synthesized ribosome to proceed from that of a free state to that of a membrane-bound state, or inversely.
The results do not establish, however, that the two populations are independent. Indeed, the kinetics suggest the possibility of a constant exchange between them.
In addition, a precursor-product relationship has been found between nuclear RNA and ribosomal RNA. The different results are discussed.
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