维生素E对非酒精性脂肪肝的治疗效果:一项开放标签的临床试验

Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) Pub Date : 2022-12-24 DOI:10.31351/vol31iss2pp135-143

Amal jawad Fairooz, Mohammed Y. Jamal, Nawal Alkhalidi

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引用次数: 0

摘要

摘要:非酒精性脂肪性肝病(NAFLD)是一种广泛存在的慢性肝病;从简单的脂肪堆积在肝脂肪变性,非酒精性脂肪肝(NASH)的炎症和肝细胞损伤 . 本研究旨在评估维生素E的影响在肝脏脂肪浸润的程度,肝酶和血脂 . 一项前瞻性开放标签临床试验涉及(39)名根据超声检查结果诊断为NAFLD的参与者，他们每天服用维生素E 800IU，持续12周，并建议采取低脂肪，低碳水化合物饮食和定期运动。脂肪变性,肝酶、空腹血糖和血脂测定基线和重复在4周内和12周内研究的时期 . 本研究结果发现，维生素E在12周显著降低脂肪变性评分(p=0.0001)，而肝酶ALT和ALP在整个研究期间无显著差异(ALT =0.081, ALP =0.117)，只有AST在整个研究期间有显著差异(12周时p=0.008)，总胆固醇和甘油三酯在4周和12周显著降低(p=0.0001)， HDL和空腹血糖在整个研究期间没有显著改变。总之，维生素E和生活方式的改变通过降低脂肪变性评分、血脂和BMI对NAFLD患者有积极的影响

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Therapeutic Effects of Vitamin E in Non-alcoholic Fatty Liver Disease: An Open-Labeled Clinical Trial

Abstract: non-alcoholic fatty liver disease (NAFLD) is one of the widespread chronic liver diseases; it is ranging from simple fat buildup in the liver (steatosis) to non-alcoholic steatohepatitis (NASH) presence of inflammation and hepatocyte injury. This study aims to assess the effect of vitamin E on the degree of fatty infiltration in the liver, liver enzymes, and lipid profile. A prospective open-labeled clinical trial involved (39) Participants diagnosed with NAFLD depending on ultrasonography findings, they were administered vitamin E 800IU\day for 12wks and advised to take low fat, low carbohydrate diet and to do regular sport. Steatosis score, liver enzymes, fasting blood sugar and lipid profile were measured at baseline and repeated at 4wks and 12wks of the study period. Results of this study found that vitamin E reduces steatosis score significantly at 12wks (p=0.0001), while liver enzymes ALT and ALP did not show significant difference throughout the study period at 12wks (p=0.081 for ALT, P=0.117 for ALP) only AST showed significant difference ( p=0.008 at 12wks ), total cholesterol and triglyceride were reduced significantly (p=0.0001 for both) at 4wks and 12wks where HDL and fasting blood glucose were not altered significantly through the study period. In conclusion, vitamin E and lifestyle modifications have a positive impact on patients with NAFLD by reducing steatosis score, lipid profile, and BMI

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Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)

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