皮肤再生的虚拟活组织检查和振动力学分析:微针和局部治疗结果的比较

F. Silver
{"title":"皮肤再生的虚拟活组织检查和振动力学分析:微针和局部治疗结果的比较","authors":"F. Silver","doi":"10.15406/jdc.2020.04.00151","DOIUrl":null,"url":null,"abstract":"Vibrational optical coherence tomography (VOCT) is a new non-invasive and non- destructive technique that can be used to image and measure the mechanical properties of skin. The technique uses infrared light and audible sound to image and measure the resonant frequency of tissue components. The stiffness (modulus) of each major tissue component is obtained from a calibration equation using values of the measured resonant frequency and tissue thickness. VOCT is used in this study to quantitatively compare the outcomes of cell proliferation and fibrous collagen deposition as a result of (1) a skin topical treatment (CE Ferulic) and (2) micro-needle roller application to human forehead skin. Both methods appear to quantitatively increase the ratio of cells to dermal collagen and the ratio of fibrotic collagen to dermal collagen with increasing time. Both chemical and mechanical treatments lead to cell proliferation and new collagen deposition using these skin rejuvenation procedures. While results obtained with micro-needle rolling are achieved more rapidly, collagen deposition with the topical is achieved painlessly. The new collagen that is deposited, using both methods, appears similar to that seen in wound healing and has a higher resonant frequency and modulus compared to normal dermal collagen. The results of this study suggest that VOCT can provide useful quantitative data to evaluate the efficacy of skin rejuvenation procedures. It is suggested that there is a need to develop techniques to regenerate normal dermal collagen as opposed to fibrotic collagen to reduce the stiffness of the new tissue formed.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Virtual biopsies and vibrational-mechanical analysis of skin rejuvenation: comparison of results obtained with micro-needling and topical treatments\",\"authors\":\"F. Silver\",\"doi\":\"10.15406/jdc.2020.04.00151\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Vibrational optical coherence tomography (VOCT) is a new non-invasive and non- destructive technique that can be used to image and measure the mechanical properties of skin. The technique uses infrared light and audible sound to image and measure the resonant frequency of tissue components. The stiffness (modulus) of each major tissue component is obtained from a calibration equation using values of the measured resonant frequency and tissue thickness. VOCT is used in this study to quantitatively compare the outcomes of cell proliferation and fibrous collagen deposition as a result of (1) a skin topical treatment (CE Ferulic) and (2) micro-needle roller application to human forehead skin. Both methods appear to quantitatively increase the ratio of cells to dermal collagen and the ratio of fibrotic collagen to dermal collagen with increasing time. Both chemical and mechanical treatments lead to cell proliferation and new collagen deposition using these skin rejuvenation procedures. While results obtained with micro-needle rolling are achieved more rapidly, collagen deposition with the topical is achieved painlessly. The new collagen that is deposited, using both methods, appears similar to that seen in wound healing and has a higher resonant frequency and modulus compared to normal dermal collagen. The results of this study suggest that VOCT can provide useful quantitative data to evaluate the efficacy of skin rejuvenation procedures. It is suggested that there is a need to develop techniques to regenerate normal dermal collagen as opposed to fibrotic collagen to reduce the stiffness of the new tissue formed.\",\"PeriodicalId\":23420,\"journal\":{\"name\":\"Ukrainian Journal of Dermatology, Venerology, Cosmetology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ukrainian Journal of Dermatology, Venerology, Cosmetology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15406/jdc.2020.04.00151\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/jdc.2020.04.00151","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

振动光学相干层析成像技术(VOCT)是一种新型的无创、无损技术,可用于对皮肤的力学特性进行成像和测量。该技术利用红外光和可听声音对组织成分的共振频率进行成像和测量。每个主要组织部件的刚度(模量)是利用测量的谐振频率和组织厚度的值从校准方程中获得的。本研究使用VOCT定量比较(1)皮肤局部治疗(CE阿魏酸)和(2)微滚针应用于人类前额皮肤后细胞增殖和纤维胶原沉积的结果。两种方法似乎都随着时间的增加而定量地增加细胞与真皮胶原的比例以及纤维化胶原与真皮胶原的比例。化学和机械治疗均可导致细胞增殖和新的胶原沉积,使用这些皮肤再生程序。虽然用微针滚动获得的结果更快,但外用胶原蛋白沉积是无痛的。使用这两种方法沉积的新胶原蛋白看起来与伤口愈合中看到的相似,并且与正常的真皮胶原蛋白相比具有更高的共振频率和模量。本研究结果表明,VOCT可以提供有用的定量数据来评估皮肤嫩肤手术的效果。建议有必要发展再生正常真皮胶原蛋白的技术,而不是纤维化胶原蛋白,以减少新组织形成的硬度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Virtual biopsies and vibrational-mechanical analysis of skin rejuvenation: comparison of results obtained with micro-needling and topical treatments
Vibrational optical coherence tomography (VOCT) is a new non-invasive and non- destructive technique that can be used to image and measure the mechanical properties of skin. The technique uses infrared light and audible sound to image and measure the resonant frequency of tissue components. The stiffness (modulus) of each major tissue component is obtained from a calibration equation using values of the measured resonant frequency and tissue thickness. VOCT is used in this study to quantitatively compare the outcomes of cell proliferation and fibrous collagen deposition as a result of (1) a skin topical treatment (CE Ferulic) and (2) micro-needle roller application to human forehead skin. Both methods appear to quantitatively increase the ratio of cells to dermal collagen and the ratio of fibrotic collagen to dermal collagen with increasing time. Both chemical and mechanical treatments lead to cell proliferation and new collagen deposition using these skin rejuvenation procedures. While results obtained with micro-needle rolling are achieved more rapidly, collagen deposition with the topical is achieved painlessly. The new collagen that is deposited, using both methods, appears similar to that seen in wound healing and has a higher resonant frequency and modulus compared to normal dermal collagen. The results of this study suggest that VOCT can provide useful quantitative data to evaluate the efficacy of skin rejuvenation procedures. It is suggested that there is a need to develop techniques to regenerate normal dermal collagen as opposed to fibrotic collagen to reduce the stiffness of the new tissue formed.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信