花石石棉:纤维宽度在间皮瘤诱发中的作用。第二部分:芬兰花石石棉职业、家庭和环境暴露的进一步流行病学研究

E. Ilgren, J. Hoskins
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引用次数: 1

摘要

尽管芬兰花青石行业所有部门的人,包括他们的家庭,都大量暴露于花青石中,但没有证据表明,甚至没有一例可归因于间皮瘤的病例。有一些病例被证实,但证据表明,它们是间皮瘤或角闪孔暴露仅仅是花青石,在每一个病例中,都是不足的。即使居住在芬兰中部卡累利阿的人口在农业和各种家庭活动以及从矿山运输过程中暴露于家庭或环境中释放的花青石,芬兰流行病学也没有发现间皮瘤的风险。在早期芬兰文献中也没有间皮瘤的报道。与暴露于其他角闪石的影响相比,这种异常现象有力地支持了纤维宽度在间皮瘤产生中的作用。然而,花青石并非没有临床效果。随着筛查技术的改进,人们发现,生活在卡累利阿的每65岁以上的人中,有三分之一患有双侧胸膜斑块。这一地区从此被称为地方性胸膜斑块区。对Kuusjarvi地区居民的放射学分析表明,这些病例是由Paakila工厂的石棉通过纤维飘流吹到30公里外造成的。后来的研究表明,“纤维漂移”不太可能是观察到的放射学结果的一个因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anthophyllite Asbestos: The Role of Fiber Width in Mesothelioma Induction Part 2: Further Epidemiological Studies of Occupational, Domestic and Environmental Exposure to Finnish Anthophyllite Asbestos
Although people in all sectors of the Finnish anthophyllite industry, including their families, have been heavily exposed to anthophyllite there is no evidence for even a single proven case of attributable mesothelioma. A few cases have been claimed but the evidence either, that they were mesotheliomas or that amphibole exposure was solely to anthophyllite is, in every case examined, insufficient. Even among the population who lived in Karelia in Central Finland who were exposed domestically or enviromentally to anthophyllite released during agricultural and various domestic activities and during transport from the mines, Finnish epidemiology found no risk of mesothelioma. There is also an absence of mesotheliomas reported in the earlier Finnish literature. This anomaly compared to the effects of exposure to other amphiboles is strong support for the role of fiber width in mesothelioma production. Anthophyllite, though, is not without clinical effect. As screening techniques improved it was discovered that of every person over the age of 65 years, one third living in Karelia had bilateral pleural plaques. The area was henceforth called the Endemic Pleural Plaque (EPP) zone. Radiographic analysis of the residents living in the district of Kuusjarvi led to suggestions that the cases resulted from asbestos blown from the Paakila facility via fiber drift as far away as 30 km. Later studies showed that ‘fiber drift’ was very unlikely to be a factor in the radiological findings thus observed.
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