Comparison of the Effect Administration Ketamine-Propofol (Ketofol) With Ketamin Single On The Quality Score Of Recovery In Patients Post Intravenous General Anesthesia As Measured By Qor-40 In Patients Undergoing Gastrointestinal Endoscopic Procedure

Introduction: Gastrointestinal endoscopy procedures cause discomfort to patients. Administration of sedation to relieve anxiety and discomfort, improve the results of the examination, and reduce the patient's memory of the event. Effective sedation can be judged by how well the drug achieves rapid onset of sedation, hemodynamic stability and fast recovery time. Ketamine maintains hemodynamic stability and sufficient depth of sedation during EGI procedures. Administering ketamine prevents bradycardia, hypotension and achieves sufficient and prolonged sedation.. Objective : This study aims to compare the effect of giving ketamine-propofol (ketofol) with ketamine alone on the recovery quality score of patients after intravenous general anesthesia as measured by QoR-40 in patients undergoing gastrointestinal endoscopy procedures. Methods : This study is a randomized blinded clinical trial. This research was conducted from July to September 2022. A total of 30 research subjects who underwent gastrointestinal endoscopy were divided into 2 groups. Group A (n=15) was given intravenous sedation Ketamine 0.5 mg/KgBW + Propofol 0.5 mg/KgBW, group B (n=15) was given Ketamine 1 mg/KgBW. The patient's recovery score was measured using the QoR-40 questionnaire 60 minutes after the endoscopy procedure was completed. Data were analyzed by univariate and bivariate. Bivariate data were analyzed by Chi-Square test, Independent T-Test and Mann-Whitney.. Results : The assessment of the safety score and the total score in this study found significant differences between the two groups with a p value <0.05. No significant difference was found in the assessment of feelings, support for patients, physical independence and pain scores with a p>0.05. Conclusion : The Ketamine-Propofol group on the comfort score and total score had higher scores than the single ketamine group, whereas on feelings, patient support, physical independence and pain scores there was no difference between the two groups.