微波谐振器的研制及电磁场对培养癌细胞的影响

Mamiko Asano
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引用次数: 1

摘要

微波既能电又能磁地渗透目标物质;然而,渗透也会受到目标物质的成分和组成的影响。这些因素使我们对微波辐射如何影响活细胞的理解复杂化,从而限制了微波辐射的治疗应用,例如在癌症治疗中。我们之前研究了微波辐射如何促进癌细胞的死亡,现在的目标是评估微波诱导细胞死亡的潜在机制。在这项研究中,我们研究了微波加热下细胞死亡的机制。首先,研制了一种能够精确控制微波能量并在碟形天线中分别产生电场和磁场的微波谐振器。该系统用于确定是电场还是磁场在微波中影响人胰腺癌细胞系Panc-1的死亡。细胞在电场强度最大的位置死亡,说明介电损耗可能影响细胞死亡。同时,在磁场强度最大的位置没有诱导细胞死亡,说明磁场可能不影响细胞死亡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of a Microwave Resonator and Effects of Electric and Magnetic Fields on Cultured Cancer Cells
: Microwaves can both electrically and magnetically permeate a target substance ; however, the permeation can also be affected by the components and composition of the target substance. These factors complicate our understanding of how microwave irradiation affects living cells, thus limiting the therapeutic application of microwave irradiation, such as in cancer treatment. We previously investigated how microwave irradiation promotes cell death in cancer cells and now aim to evaluate the potential mechanisms underlying microwave-induced cell death. In this study, we investigated the mechanism underlying cell death in response to microwave heating. First, a microwave resonator that could precisely control microwave energy and separately generate an electric field and a magnetic field in a dish was developed. This system was employed to confirm whether it is the electric or the magnetic field in the microwave that affects the death of the human pancreatic carcinoma cell line, Panc-1. Cells were killed at the position where the electric field strength was at a maximum, suggesting that dielectric loss might affect cell death. Meanwhile, cell death was not induced at the position where the magnetic field strength was at a maximum, suggesting that the magnetic field might not affect cell death.
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