局部使用阿米替林和亚油酸恢复神经酰胺变阻器在特应性皮炎病变- 1例报告。

M. Blaess, F. Wenzel, R. Csuk, H. Deigner
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引用次数: 2

摘要

重建、稳定和维持皮肤脂质屏障是治疗和预防特应性皮炎的一种令人鼓舞的疾病管理理念(缓解和护理)。然而,预防和局部治疗缺乏一种简单、安全、有效和模块化的方法。几十年来,特应性皮炎的主要局部治疗一直是皮质类固醇,创新是罕见的。我们的病例报告展示了一个病人的斗争与瘙痒性皮肤病变和皮肤病变的复发,根据目前的治疗指南,证明是无效的。因此,我们决定尝试一种先进的c16 -神经酰胺病理机制衍生的局部治疗措施,因为它提供了重建皮肤和减轻痛苦的希望。阿米替林联合亚油酸提供了一个机会,从干燥和瘙痒的皮肤,轻度至中度特应性皮炎病变的释放,没有已知的严重的不良反应,局部皮质类固醇,同时防止复发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Topical use of amitriptyline and linoleic acid to restore ceramide rheostat in atopic dermatitis lesions - a case report.
Rebuilding, stabilizing and maintaining the dermal lipid barrier is an encouraging disease management concept (relief and care) in the treatment and prevention of atopic dermatitis. Prevention and topical treatment, however, lack a simple, safe, effective and modular approach. For decades, the mainstay of topical therapy of atopic dermatitis has been corticosteroids, with innovations being rare. Our case report demonstrates the struggle of a patient with little relief of itchy dermal lesions and the recurrence of skin lesions following current therapeutic guidelines which proved to be ineffective. Therefore we decided to try an advanced C16-ceramide pathomechanism derived topical therapeutic measure since it offers hope of re-establishing skin and alleviating suffering. Amitriptyline in combination with linoleic acid offers a chance to release from dry and itchy skin, mild to moderate atopic dermatitis lesions without known serious adverse effects of topical corticosteroids, while preventing recurrence.
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