Ayu Matsunaga, Kurumi Takagi-Matsumoto, M. Yamashita, Kumiko Kizu-Mori, Junko Hirose, T. Kabuki, F. Sakai, Hiroshi Narita
{"title":"乳酸菌SBT2055通过母乳喂养增强小鼠的口服耐受性","authors":"Ayu Matsunaga, Kurumi Takagi-Matsumoto, M. Yamashita, Kumiko Kizu-Mori, Junko Hirose, T. Kabuki, F. Sakai, Hiroshi Narita","doi":"10.4327/JSNFS.72.105","DOIUrl":null,"url":null,"abstract":"Summary : Maternal administration of probiotics is known to be effective for prevention of allergic symptoms in babies by suppressing the immune reaction to orally ingested proteins ( oral tolerance ) . We investigated whether breast milk nourishment by mother mice that had been orally administrated Lactobacillus gasseri SBT 2055 ( LG 2055) with food antigen contributed to allergy prevention in their pups. Female BALB/c mice ( dams ) were fed a diet containing casein ( C group ) , egg white ( E group ) , or egg white with LG 2055 ( E + LG group ) . After induction of pregnancy, pups fed on their dam ʼ s milk were systemically immunized with ovalbu-min ( OVA ) . Then, at the age of seven weeks, the pups were given an intragastric OVA challenge. The incidence of diarrhea was significantly suppressed in pups of the E + LG group relative to the E group. Moreover, the amounts of total IgA and OVA-specific IgA immune complex ( IgA-IC ) in the breast milk were significantly in-creased by administration of LG 2055 . These findings suggest that the increase of IgA-IC in breast milk by LG 2055 might closely correlate with enhancement of oral tolerance in pups.","PeriodicalId":19296,"journal":{"name":"Nippon Eiyo Shokuryo Gakkaishi","volume":"23 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lactobacillus gasseri SBT2055 Enhances Oral Tolerance in Mice via Breastfeeding\",\"authors\":\"Ayu Matsunaga, Kurumi Takagi-Matsumoto, M. Yamashita, Kumiko Kizu-Mori, Junko Hirose, T. Kabuki, F. Sakai, Hiroshi Narita\",\"doi\":\"10.4327/JSNFS.72.105\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Summary : Maternal administration of probiotics is known to be effective for prevention of allergic symptoms in babies by suppressing the immune reaction to orally ingested proteins ( oral tolerance ) . We investigated whether breast milk nourishment by mother mice that had been orally administrated Lactobacillus gasseri SBT 2055 ( LG 2055) with food antigen contributed to allergy prevention in their pups. Female BALB/c mice ( dams ) were fed a diet containing casein ( C group ) , egg white ( E group ) , or egg white with LG 2055 ( E + LG group ) . After induction of pregnancy, pups fed on their dam ʼ s milk were systemically immunized with ovalbu-min ( OVA ) . Then, at the age of seven weeks, the pups were given an intragastric OVA challenge. The incidence of diarrhea was significantly suppressed in pups of the E + LG group relative to the E group. Moreover, the amounts of total IgA and OVA-specific IgA immune complex ( IgA-IC ) in the breast milk were significantly in-creased by administration of LG 2055 . These findings suggest that the increase of IgA-IC in breast milk by LG 2055 might closely correlate with enhancement of oral tolerance in pups.\",\"PeriodicalId\":19296,\"journal\":{\"name\":\"Nippon Eiyo Shokuryo Gakkaishi\",\"volume\":\"23 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nippon Eiyo Shokuryo Gakkaishi\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4327/JSNFS.72.105\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nippon Eiyo Shokuryo Gakkaishi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4327/JSNFS.72.105","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Lactobacillus gasseri SBT2055 Enhances Oral Tolerance in Mice via Breastfeeding
Summary : Maternal administration of probiotics is known to be effective for prevention of allergic symptoms in babies by suppressing the immune reaction to orally ingested proteins ( oral tolerance ) . We investigated whether breast milk nourishment by mother mice that had been orally administrated Lactobacillus gasseri SBT 2055 ( LG 2055) with food antigen contributed to allergy prevention in their pups. Female BALB/c mice ( dams ) were fed a diet containing casein ( C group ) , egg white ( E group ) , or egg white with LG 2055 ( E + LG group ) . After induction of pregnancy, pups fed on their dam ʼ s milk were systemically immunized with ovalbu-min ( OVA ) . Then, at the age of seven weeks, the pups were given an intragastric OVA challenge. The incidence of diarrhea was significantly suppressed in pups of the E + LG group relative to the E group. Moreover, the amounts of total IgA and OVA-specific IgA immune complex ( IgA-IC ) in the breast milk were significantly in-creased by administration of LG 2055 . These findings suggest that the increase of IgA-IC in breast milk by LG 2055 might closely correlate with enhancement of oral tolerance in pups.