宿主对关节炎源性甲病毒感染的免疫反应,重点是I型干扰素反应

Patrick Chun Hean Tang, Wern Hann Ng, Xiang Liu
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引用次数: 2

摘要

关节炎源性甲病毒,如罗斯河病毒、基孔肯雅病毒和O 'nyong-nyong病毒,在全球引起地方病,是一个主要的公共卫生问题。关节炎源性甲病毒病的特征是使人衰弱的疼痛,以及潜在的慢性肌肉炎症,从而影响生活质量。I型IFN应答是先天免疫应答针对关节炎性甲病毒的主要组成部分,在抑制病毒复制和传播中是必不可少的。I型干扰素在感染的早期阶段被诱导,是激活抗病毒先天免疫反应所必需的。它们还将先天免疫反应和适应性免疫的激活联系起来。这篇综述的重点是宿主免疫反应,特别是涉及I型干扰素,在关节炎源性甲病毒病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN Responses
Arthritogenic alphaviruses, such as Ross River virus, chikungunya virus and O’nyong-nyong virus, cause endemic disease globally and are a major public health concern. The hallmarks of arthritogenic alphavirus disease are debilitating pain, and potentially chronic inflammation of the muscles, thus influencing quality of life. The type I IFN response is a major component of the innate immune response against arthritogenic alphaviruses, and is essential in inhibiting viral replication and dissemination. Type I IFNs are induced during early stages of infection and are essential for the activation of the antiviral innate immune response. They also link the innate immune response and the activation of adaptive immunity. This review focuses on the host immune response, particularly that involving type I IFN, in arthritogenic alphavirus disease.
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