一种利用外膜囊泡增强肿瘤RGD靶向治疗的化学免疫联合疗法。

IF 4.2 2区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2022-10-01 DOI:10.2139/ssrn.4156334

Shuping Li, Xiaodong Gao

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引用次数: 1

摘要

由于药物渗透性差，阻碍了肿瘤的有效治疗，癌症治疗受到了限制。本研究通过将诱导免疫反应的细菌外膜囊泡(OMVs)和阿霉素(DOX)纳米载体通过孵育加载到天然免疫平台OMV中，克服了这一问题。利用omv表面的靶向肽6-Mal- arg - gy - asp (RGD)，通过与细胞表面整合素αvβ3结合，增加药物内化，提高了药物在肿瘤部位的蓄积。omv通过降低TAM和Treg，增加CD8+ T和M1，促进DC成熟来逆转免疫抑制性肿瘤微环境(TME)，从而刺激免疫应答。DOX和omv的联合治疗弥补了单一治疗(如化疗和免疫治疗)的不足，提高了癌症治疗的疗效，同时有助于选择新的纳米载体和开发有效的治疗方案。

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A combinational chemo-immune therapy using outer membrane vesicles for enhanced cancer therapy by RGD targeting.

Cancer therapies are limited by poor drug penetration that impedes effective tumor treatment. This was overcome in the present study by loading the immune reaction inducing nanocarriers of the bacterial outer membrane vesicles (OMVs) and doxorubicin (DOX) into the natural immunity platform OMV via incubation. Drug accumulation at the tumor site was improved by using the targeting peptide 6-Mal- Arg-Gly-Asp (RGD) on the surface of OMVs to increase internalization via binding to cell surface integrin αvβ3. OMVs stimulate immune responses by reversing the immune-suppressive tumor microenvironment (TME) via decreasing TAM and Treg, increasing CD8+ T and M1, and promoting DC maturation. The combination of DOX and OMVs compensates for the shortcomings of monotherapy (e.g., chemotherapy and immunotherapy) and amplifies the therapeutic efficacy of cancer treatment, while aiding selection of novel nanocarriers and development of effective therapeutic regimens.

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来源期刊

Nanomedicine : nanotechnology, biology, and medicine 工程技术-纳米科技

CiteScore

11.10

自引率

0.00%

发文量

133

审稿时长

42 days

期刊介绍： The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.