COMPARATIVE ASSESSMENT OF COMPREHENSIVE DRUGS BASED ON IMIDACLOPRID AND MOXYDECTIN FOR ECTO- AND ENDOPARASITIC INVASIONS OF DOGS

The article presents data on the effectiveness of the new domestic complex antiparasitic drug "Megastop ultra for dogs" in comparison with the reference drug "Advokat@ for dogs" when used for the treatment and prevention of ecto- and endoparasitic infestations in dogs of different breeds, ages, sexes and body weights. Based on the results of an entomological examination of the dogs of the experimental and control groups, parasitism of fleas of the species Ctenocephalus canis and Pulex irritans with an intensity of infestation of 110 to 140 fleas per animal and hair eaters of the species Trichodectes canis with an intensity of infestation of 15 to 32 instances of hair eaters per 100 cm² was found on their bodies. surface of the animal's body. Clinical signs of ectoparasite infection included skin irritation, scabbing, dermatitis, and pruritus. After treating dogs with the drug "Megastop ultra for dogs" for 8 hours, its effectiveness against siphonapterosis in dogs was 89.9 %, and after using the reference drug "Advokat@ for dogs" – 91.9 %. Starting from the first and third day after using the drugs, no fleas were found on the dogs' bodies. For trichodectosis in dogs, after using the drug "Megastop ultra for dogs" on the 1st day, its effectiveness was 91.4 %, and after using the comparison drug "Advokat@ for dogs" – 93.8 %. At the same time, 2 and 7 days after treatment with drugs, no live hair-eating ectoparasite dogs were found. According to the results of the parasitological studies, the animals of the experimental and control groups were found to be spontaneously affected by endoparasites – causative agents of nematodes of the alimentary canal: Toxocara canis with an intensity of infestation (II) from 100 to 170 eggs in one gram of feces (ЕGF)s, Ancylostoma caninum – from 40 to 56 ЕGF and Trichuris vulpis – from 56 to 76 ЕGF. Clinically, nematodes in dogs were manifested by: deterioration of appetite, depression, paleness of mucous membranes, and in some animals, vomiting and mild diarrhea. After deworming, helminthocoprological studies were carried out with the establishment of indices of parasitological damage and determination of the intensive effectiveness (IE) and extensive effectiveness (EE) of the drugs. On the basis of the obtained results, it was established that for spontaneous toxocariasis in dogs on the 7th day after deworming, the intensity of the drug "Megastop ultra for dogs" was 94.8 %, and the reference drug "Advokat@ for dogs" was 97.6 %. On the 14th day after deworming the animals, the extensive and intensive effectiveness of both drugs was 100 %. Helminthological studies established that for spontaneous hookworm infestation in dogs 7 and 14 days after the use of the researched drug and the reference drug in the recommended doses, the intensive and extensive effectiveness of veterinary drugs was 100 %. In the case of spontaneous trichurosis infestation of dogs, it was established that on the 7th and 14th day after deworming, the intensity of the studied drug was 90.0 and 96.7 %, and the intensity of the reference drug was 91.9 and 98.6 %, respectively. Field tests have shown that the research drugs are easy to use, well tolerated by animals regardless of breed, age, sex, and body weight, and do not have a toxic effect on the animal's body when they are used once by the "spot-on" method in the manufacturer's recommended doses.