固化时间对ph值及时间依赖性的影响

International journal of health research and innovation Pub Date : 2010-06-09 DOI:10.4314/IJHR.V2I1.55394

V. D. Kadam, S. Gattani

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引用次数: 3

摘要

目的:包衣微丸的药物释放取决于许多工艺和配方变量，包括塑化，固化处理和核心的性质。本研究考察了咖喱对苦苣苔包被微丸的影响。方法:将茶碱负载的微球包被一种非水时间和pH依赖的乌龙茶溶液。包被微丸在恒定工艺参数(45°C)下固化不同时间(05、10或20分钟)，并评估药物释放曲线和制剂的其他特性。结果:体外释放实验表明，包被微丸对药物释放有延缓作用。DSC热像图显示配方中的聚合物与药物之间没有相互作用。SEM数据显示，固化20 min后，表面形貌没有变化。结论:一般情况下，固化降低了药物释放，使药物释放曲线稳定。关键词:时间和pH依赖性聚合物;球团固化;

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Effect of curing time on ph and time dependant coated pellets

PURPOSE: The drug release from coated pellets depends on many process and formulation variables, including plasticization, curing treatment, and properties of the core. In this study, effect of currying on eudragit coated pellets was investigated. METHODS: Theophylline loaded pellets were coated with a non aqueous time and pH dependant eudragit solution. The coated pellets were cured at constant process parameters (45°C) for different time periods (05, 10, or 20 min) and the drug release profile and other characteristics of formulation were evaluated. RESULTS: In vitro release studies shows retardation of drug release from the coated pellets. The DSC thermogram revealed no interaction between the polymer and drug in the formulation. The SEM data shows no change in the surface topography after 20 min curing. CONCLUSION: In general, curing reduced the drug release and resulted in stable drug release profiles. Keywords: Time and pH dependant polymers, curing of pellets.

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International journal of health research and innovation

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