{"title":"中央神经抑制系统1","authors":"","doi":"10.33263/lianbs123.073","DOIUrl":null,"url":null,"abstract":"1-Aryl-2-mercapto-4-(phenyl/p-chlorophenyl)-imidazoles (Ia-1) were condensed with 2-chloromethyl benzimidazole (II) in presence of sodium hydroxide in ethanol to get 1-aryl-2-thiomethylene benzimidazol-2-yl-4-(phenyl/p-chlorophenyl)-imidazoles (IIIa-1). These compounds (IIIa-1) were subsequently oxidised by hydrogen peroxide to get 1-aryl-2-sulphono-[benzimidazol-2-yl]-methyl-4 and (phenyl/p-chlorophenyl)-imidazoles (Iva-1). All the compounds (IIIa-1) and (Iva-1) exhibited central nervous system depressant action on albino mice. All the compounds are non-toxic and possess some sedative activity.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"17 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Central Nervous System Activity of 1-aryl-2(thiomethylene benzimidazol-2-yl)-4-(phenyl/p-chlorophenyl)-imidazoles and 1-aryl-2-sulphono-[benzimidazol-2-yl]-methyl-4-(phenyl/p-chlorophenyl)-imidazoles\",\"authors\":\"\",\"doi\":\"10.33263/lianbs123.073\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"1-Aryl-2-mercapto-4-(phenyl/p-chlorophenyl)-imidazoles (Ia-1) were condensed with 2-chloromethyl benzimidazole (II) in presence of sodium hydroxide in ethanol to get 1-aryl-2-thiomethylene benzimidazol-2-yl-4-(phenyl/p-chlorophenyl)-imidazoles (IIIa-1). These compounds (IIIa-1) were subsequently oxidised by hydrogen peroxide to get 1-aryl-2-sulphono-[benzimidazol-2-yl]-methyl-4 and (phenyl/p-chlorophenyl)-imidazoles (Iva-1). All the compounds (IIIa-1) and (Iva-1) exhibited central nervous system depressant action on albino mice. All the compounds are non-toxic and possess some sedative activity.\",\"PeriodicalId\":18009,\"journal\":{\"name\":\"Letters in Applied NanoBioScience\",\"volume\":\"17 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Letters in Applied NanoBioScience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33263/lianbs123.073\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Letters in Applied NanoBioScience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33263/lianbs123.073","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Central Nervous System Activity of 1-aryl-2(thiomethylene benzimidazol-2-yl)-4-(phenyl/p-chlorophenyl)-imidazoles and 1-aryl-2-sulphono-[benzimidazol-2-yl]-methyl-4-(phenyl/p-chlorophenyl)-imidazoles
1-Aryl-2-mercapto-4-(phenyl/p-chlorophenyl)-imidazoles (Ia-1) were condensed with 2-chloromethyl benzimidazole (II) in presence of sodium hydroxide in ethanol to get 1-aryl-2-thiomethylene benzimidazol-2-yl-4-(phenyl/p-chlorophenyl)-imidazoles (IIIa-1). These compounds (IIIa-1) were subsequently oxidised by hydrogen peroxide to get 1-aryl-2-sulphono-[benzimidazol-2-yl]-methyl-4 and (phenyl/p-chlorophenyl)-imidazoles (Iva-1). All the compounds (IIIa-1) and (Iva-1) exhibited central nervous system depressant action on albino mice. All the compounds are non-toxic and possess some sedative activity.
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