基于致病性的COVID-19治疗

Ali Salimi Asl, F. Malekzadeh, A. Nikpoor, Shaghayegh Kermaninezhad, Sobhan Montazerghaem
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引用次数: 1

摘要

新型冠状病毒于2019年12月首次在中国被发现,随后在全球范围内引发了大流行。目前还没有确切的治疗方法,也不可能很快研制出疫苗。病毒的致病机制包括病毒侵入、与宿主细胞表面血管紧张素转换酶2 (ACE2)受体结合、增殖、膜融合、组装、后续感染、细胞因子分泌和宿主对病毒的免疫应答。通过确定患者处于哪个阶段,可以使用可能有效的药物来控制每个阶段。因此,确定病毒在疾病不同阶段的作用机制,可以针对疾病的每个阶段使用合适的药物,从而控制疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COVID-19 Treatments Based on Pathogenicity
The new coronavirus was first identified in China in December 2019 and then, it created a widespread pandemic around the world. There is currently no definitive cure for it and it will not be possible to make a vaccine soon. Pathogenic mechanism of the virus includes virus entry, binding to angiotensin-converting enzyme 2 (ACE2) receptors on the surface of host cells, proliferation, membrane fusion, assembly, subsequent infection, cytokine secretion, and the host immune response to the virus. By identifying at what stage the patient is, possible effective drugs can be used to control each stage. Therefore, identifying the mechanism of action of the virus in different stages of the disease makes it possible to use the appropriate drug for each stage of the disease and control the disease.
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