绿茶对大鼠暴露于醋酸甲氧孕酮的降低胆固醇/高密度脂蛋白c比值的作用

Elly Susilawati, W. Barlianto, I. Wiyasa
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引用次数: 3

摘要

目的:研究绿茶提取物是否能降低大鼠暴露于醋酸甲孕酮(DMPA)后的低密度脂蛋白-胆固醇(LDL-c)和增高高密度脂蛋白(HDL)-c。方法:25只雌性Wistar大鼠分为5组,每组5只:(1)阴性对照;(2)阳性对照,仅接受DMPA治疗;(3) DMPA加绿茶提取物10.8 mg/kg/d;(4) DMPA加绿茶提取物21.6 mg/kg/d;(5) DMPA加绿茶提取物,剂量为43.2 mg/kg/d。用绿茶进行了四周的治疗。结果:与未治疗组相比,DMPA显著改变了血清脂质特征,表现为HDL降低、LDL升高、胆固醇/HDL-c比值升高。低密度脂蛋白的增加在绿茶的所有处理剂量下都明显减弱。同样,所有剂量的提取物都显著减轻了HDL水平的下降。另一方面,最低和最高剂量的绿茶提取物显著降低了DMPA组中胆固醇/高密度脂蛋白c比率的升高水平。结论:绿茶提取物对DMPA诱导的LDL-c和胆固醇/HDL-c比值升高具有抑制作用。这可能为使暴露于DMPA的受试者的脂质状况正常化提供一种天然的治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cholesterol/HDL-c ratio lowering effect of green tea in rats exposed to depot medroxiprogesterone acetate -
Objective: This study aimed to investigate whether an extract of green tea is able to decrease low density lipoprotein-cholesterol (LDL-c) and increase high density lipoprotein (HDL)-c in rats exposed to depot medroxyprogesterone acetate (DMPA). Methods: Twenty five female Wistar rats were divided into five groups (n = 5 each): (1) untreated negative control; (2) positive control which received DMPA only; (3) DMPA plus green tea extract at the dose of 10.8 mg/kg/day; (4) DMPA plus green tea extract at the dose of 21.6 mg/kg/day; (5) and DMPA plus green tea extract at the dose of 43.2 mg/kg/day. The treatment with green tea was performed for four weeks. Serum lipid profile and atherogenic index were analyzed by automated enzymatic technique Results: DMPA significantly changed the serum lipid profile marked by decreased HDL, increased LDL and cholesterol/HDL-c ratio compared with the untreated group. The increase in LDL was significantly attenuated by all treatment doses of of green tea. Similarly, the decrease in HDL level was significantly attenuated by all doses of the extract. On the other hand, increased levels of cholesterol/HDL-c ratio in the DMPA group was significantly reduced by lowest and highest doses of green tea extract. Conclusion: Green tea extract inhibits the increase in LDL-c and cholesterol/HDL-c ratio induced by DMPA. This may provide a natural therapeutic alternative for normalizing the lipid profile found in subjects exposed to DMPA.
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