Gustavo Matus-Miranda , Antonio Mancilla , René Martinez , Maureen Marshall , Juan Pablo Aravena-Salazar , María José Quijarro , Víctor Moraga
{"title":"生物标志物在预测药物相关性颌骨坏死发展中的作用：范围综述","authors":"Gustavo Matus-Miranda , Antonio Mancilla , René Martinez , Maureen Marshall , Juan Pablo Aravena-Salazar , María José Quijarro , Víctor Moraga","doi":"10.1016/j.ajoms.2023.09.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p><span><span>Medication-related osteonecrosis of the jaws<span> (MRONJ) is a severe reaction consisting of progressive destruction of maxillofacial bone tissue caused mainly by antiresorptive and </span></span>antiangiogenic drugs. The aim of this scoping review is to identify biomarkers that can predict the development of MRONJ </span>in patients<span> undergoing dental treatment.</span></p></div><div><h3>Methods</h3><p>A scoping review was performed, using PubMed/MEDLINE, Web of Science and Scopus databases using the search formula with MesH terms: “(((((\"Bisphosphonate-Associated Osteonecrosis of the Jaw\"[Mesh]) OR \"Osteonecrosis\"[Mesh]) AND \"Maxilla\"[Mesh]) OR \"Mandible\"[Mesh]) AND \"Oral Surgical Procedures\"[Mesh]) OR \"Surgery, Oral\"[Mesh]”. Inclusion and exclusion criteria were applied for article selection.</p></div><div><h3>Results</h3><p>We found 113 articles and screened 80 publications. After, 30 manuscripts remained for full-text evaluation. Twenty were discarded for not being related to the proposed objectives, leaving 9 articles included for qualitative analysis.</p></div><div><h3>Discussion</h3><p><span><span>Several biomarkers considered as possible predictors of MRONJ development were found: bone alkaline phosphatase (BAP), </span>parathyroid hormone (PTH), </span>osteocalcin<span><span> (OC), procollagen type 1 amino terminal propeptide (P1NP), N-terminal telopeptide of </span>collagen type I<span><span> (NTX), interleukin 6 (IL-6), deoxypyridinoline (DPD), </span>25 hydroxyvitamin D<span> (25OHD), creatinine and total calcium, white blood cells (WBC), serum albumin (ALB), hemoglobin (HB), total cholesterol (CHL), C-reactive protein (CRP) and serum alkaline phosphatase (ALP). The most evaluated was C-terminal telopeptide of collagen type I (CTX).</span></span></span></p></div><div><h3>Conclusion</h3><p>The use of predictive biomarkers would represent, for the population consuming drugs associated with osteonecrosis of the jaws, an advance and improvement in the planning of appropriate treatments<span> and in their quality of life. Currently, it has not yet been possible to establish one or more specific biomarkers capable of predicting the development of MRONJ.</span></p></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Utility of biomarkers in predicting the development of medication-related osteonecrosis of the jaws: A scoping review\",\"authors\":\"Gustavo Matus-Miranda , Antonio Mancilla , René Martinez , Maureen Marshall , Juan Pablo Aravena-Salazar , María José Quijarro , Víctor Moraga\",\"doi\":\"10.1016/j.ajoms.2023.09.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p><span><span>Medication-related osteonecrosis of the jaws<span> (MRONJ) is a severe reaction consisting of progressive destruction of maxillofacial bone tissue caused mainly by antiresorptive and </span></span>antiangiogenic drugs. The aim of this scoping review is to identify biomarkers that can predict the development of MRONJ </span>in patients<span> undergoing dental treatment.</span></p></div><div><h3>Methods</h3><p>A scoping review was performed, using PubMed/MEDLINE, Web of Science and Scopus databases using the search formula with MesH terms: “(((((\\\"Bisphosphonate-Associated Osteonecrosis of the Jaw\\\"[Mesh]) OR \\\"Osteonecrosis\\\"[Mesh]) AND \\\"Maxilla\\\"[Mesh]) OR \\\"Mandible\\\"[Mesh]) AND \\\"Oral Surgical Procedures\\\"[Mesh]) OR \\\"Surgery, Oral\\\"[Mesh]”. Inclusion and exclusion criteria were applied for article selection.</p></div><div><h3>Results</h3><p>We found 113 articles and screened 80 publications. After, 30 manuscripts remained for full-text evaluation. Twenty were discarded for not being related to the proposed objectives, leaving 9 articles included for qualitative analysis.</p></div><div><h3>Discussion</h3><p><span><span>Several biomarkers considered as possible predictors of MRONJ development were found: bone alkaline phosphatase (BAP), </span>parathyroid hormone (PTH), </span>osteocalcin<span><span> (OC), procollagen type 1 amino terminal propeptide (P1NP), N-terminal telopeptide of </span>collagen type I<span><span> (NTX), interleukin 6 (IL-6), deoxypyridinoline (DPD), </span>25 hydroxyvitamin D<span> (25OHD), creatinine and total calcium, white blood cells (WBC), serum albumin (ALB), hemoglobin (HB), total cholesterol (CHL), C-reactive protein (CRP) and serum alkaline phosphatase (ALP). The most evaluated was C-terminal telopeptide of collagen type I (CTX).</span></span></span></p></div><div><h3>Conclusion</h3><p>The use of predictive biomarkers would represent, for the population consuming drugs associated with osteonecrosis of the jaws, an advance and improvement in the planning of appropriate treatments<span> and in their quality of life. Currently, it has not yet been possible to establish one or more specific biomarkers capable of predicting the development of MRONJ.</span></p></div>\",\"PeriodicalId\":45034,\"journal\":{\"name\":\"Journal of Oral and Maxillofacial Surgery Medicine and Pathology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2023-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Oral and Maxillofacial Surgery Medicine and Pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S221255582300203X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221255582300203X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
引言与药物相关的颌骨坏死（MRONJ）是一种严重的反应，主要由抗骨质吸收药物和抗血管生成药物引起的颌面部骨组织进行性破坏。本范围综述旨在确定可预测接受牙科治疗的患者发生 MRONJ 的生物标志物。方法利用 PubMed/MEDLINE、Web of Science 和 Scopus 数据库进行了范围综述，使用的检索公式为 MesH terms："((((("Bisphosphonate-Associated Osteonecrosis of the Jaw"[Mesh]) OR "Osteonecrosis"[Mesh]) AND "Maxilla"[Mesh]) OR "Mandible"[Mesh]) AND "Oral Surgical Procedures"[Mesh]) OR "Surgery, Oral"[Mesh]" 。结果我们共找到 113 篇文章，筛选出 80 篇出版物。之后，剩下 30 篇稿件进行全文评估。其中 20 篇因与拟议目标无关而被剔除，剩下 9 篇文章被纳入定性分析。讨论发现了几种可能预测 MRONJ 发展的生物标志物：骨碱性磷酸酶（BAP）、甲状旁腺激素（PTH）、骨钙素（OC）、1 型胶原蛋白氨基端前肽（P1NP）、I 型胶原蛋白 N 端端肽（NTX）、白细胞介素 6（IL-6）、脱氧吡啶啉（DPD）、25羟维生素 D（25OHD）、肌酐和总钙、白细胞（WBC）、血清白蛋白（ALB）、血红蛋白（HB）、总胆固醇（CHL）、C 反应蛋白（CRP）和血清碱性磷酸酶（ALP）。结论预测性生物标志物的使用对于服用颌骨骨坏死相关药物的人群来说，代表着在规划适当的治疗和提高其生活质量方面的进步和改善。目前，尚无法确定一种或多种能够预测 MRONJ 发展的特异性生物标志物。
Utility of biomarkers in predicting the development of medication-related osteonecrosis of the jaws: A scoping review
Introduction
Medication-related osteonecrosis of the jaws (MRONJ) is a severe reaction consisting of progressive destruction of maxillofacial bone tissue caused mainly by antiresorptive and antiangiogenic drugs. The aim of this scoping review is to identify biomarkers that can predict the development of MRONJ in patients undergoing dental treatment.
Methods
A scoping review was performed, using PubMed/MEDLINE, Web of Science and Scopus databases using the search formula with MesH terms: “((((("Bisphosphonate-Associated Osteonecrosis of the Jaw"[Mesh]) OR "Osteonecrosis"[Mesh]) AND "Maxilla"[Mesh]) OR "Mandible"[Mesh]) AND "Oral Surgical Procedures"[Mesh]) OR "Surgery, Oral"[Mesh]”. Inclusion and exclusion criteria were applied for article selection.
Results
We found 113 articles and screened 80 publications. After, 30 manuscripts remained for full-text evaluation. Twenty were discarded for not being related to the proposed objectives, leaving 9 articles included for qualitative analysis.
Discussion
Several biomarkers considered as possible predictors of MRONJ development were found: bone alkaline phosphatase (BAP), parathyroid hormone (PTH), osteocalcin (OC), procollagen type 1 amino terminal propeptide (P1NP), N-terminal telopeptide of collagen type I (NTX), interleukin 6 (IL-6), deoxypyridinoline (DPD), 25 hydroxyvitamin D (25OHD), creatinine and total calcium, white blood cells (WBC), serum albumin (ALB), hemoglobin (HB), total cholesterol (CHL), C-reactive protein (CRP) and serum alkaline phosphatase (ALP). The most evaluated was C-terminal telopeptide of collagen type I (CTX).
Conclusion
The use of predictive biomarkers would represent, for the population consuming drugs associated with osteonecrosis of the jaws, an advance and improvement in the planning of appropriate treatments and in their quality of life. Currently, it has not yet been possible to establish one or more specific biomarkers capable of predicting the development of MRONJ.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
