锂诱导的神经可塑性

R. Mukhopadhyaya, M. Rajadhyaksha
{"title":"锂诱导的神经可塑性","authors":"R. Mukhopadhyaya, M. Rajadhyaksha","doi":"10.4103/2349-3666.240597","DOIUrl":null,"url":null,"abstract":"Neural plasticity refers to the brain’s ability to make new cellular connections. Drugs that can induce neural plasticity are of basic as well as clinical interest. Lithium, a drug already in use, has been demonstrated to be neuroprotective and is likely to find wider use. The spectrum of diseases that can be potentially treated with lithium suggests that there could be a common cellular mechanism, such as neural plasticity, in operation. We review effects of lithium on major cellular processes that comprise neuroplasticity – alterations, in vitro and in vivo, in neurites, axons and synapse formation. Lithium is known to support extension of cytoplasmic outgrowths. Lithium alters patterns of axonal modifications including their extensions or retractions and sprouting of new branches. However, there are few studies directly demonstrating lithium action of synapse formation. The molecular basis of lithium action is complex with various pathways involved in cross talk. Of these multiple pathways, we have focused on lithium induced inhibition of glycogen synthase kinase-3β, block of inositol phosphate pathway and up regulation of neurotrophins as there are direct evidences of involvement of these in lithium induced neuroplasticity. This review provides a bird’s eye view of studies that could provide insight into special aspect of lithium action, induction of plasticity, which have implication for treating a wide variety of neurological conditions","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lithium induced neural plasticity\",\"authors\":\"R. Mukhopadhyaya, M. Rajadhyaksha\",\"doi\":\"10.4103/2349-3666.240597\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Neural plasticity refers to the brain’s ability to make new cellular connections. Drugs that can induce neural plasticity are of basic as well as clinical interest. Lithium, a drug already in use, has been demonstrated to be neuroprotective and is likely to find wider use. The spectrum of diseases that can be potentially treated with lithium suggests that there could be a common cellular mechanism, such as neural plasticity, in operation. We review effects of lithium on major cellular processes that comprise neuroplasticity – alterations, in vitro and in vivo, in neurites, axons and synapse formation. Lithium is known to support extension of cytoplasmic outgrowths. Lithium alters patterns of axonal modifications including their extensions or retractions and sprouting of new branches. However, there are few studies directly demonstrating lithium action of synapse formation. The molecular basis of lithium action is complex with various pathways involved in cross talk. Of these multiple pathways, we have focused on lithium induced inhibition of glycogen synthase kinase-3β, block of inositol phosphate pathway and up regulation of neurotrophins as there are direct evidences of involvement of these in lithium induced neuroplasticity. This review provides a bird’s eye view of studies that could provide insight into special aspect of lithium action, induction of plasticity, which have implication for treating a wide variety of neurological conditions\",\"PeriodicalId\":34293,\"journal\":{\"name\":\"Biomedical Research Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical Research Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/2349-3666.240597\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Research Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/2349-3666.240597","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

神经可塑性指的是大脑建立新细胞连接的能力。诱导神经可塑性的药物具有重要的基础和临床意义。锂,一种已经在使用的药物,已经被证明具有神经保护作用,并且可能会得到更广泛的应用。可以用锂治疗的一系列疾病表明,可能有一种共同的细胞机制在起作用,比如神经可塑性。我们回顾了锂对主要细胞过程的影响,包括神经可塑性的改变,在体外和体内,在神经突,轴突和突触形成。已知锂支持细胞质生长的延伸。锂改变了轴突修饰的模式,包括它们的延伸或收缩以及新分支的萌发。然而,很少有研究直接证明锂对突触形成的作用。锂离子作用的分子基础是复杂的,串扰涉及多种途径。在这些多种途径中,我们重点关注锂诱导的糖原合成酶激酶-3β的抑制,肌醇磷酸途径的阻断和神经营养因子的上调,因为有直接证据表明这些参与了锂诱导的神经可塑性。这篇综述提供了一个鸟瞰图的研究,可以提供洞察锂作用的特殊方面,可塑性的诱导,这对治疗各种神经系统疾病具有重要意义
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lithium induced neural plasticity
Neural plasticity refers to the brain’s ability to make new cellular connections. Drugs that can induce neural plasticity are of basic as well as clinical interest. Lithium, a drug already in use, has been demonstrated to be neuroprotective and is likely to find wider use. The spectrum of diseases that can be potentially treated with lithium suggests that there could be a common cellular mechanism, such as neural plasticity, in operation. We review effects of lithium on major cellular processes that comprise neuroplasticity – alterations, in vitro and in vivo, in neurites, axons and synapse formation. Lithium is known to support extension of cytoplasmic outgrowths. Lithium alters patterns of axonal modifications including their extensions or retractions and sprouting of new branches. However, there are few studies directly demonstrating lithium action of synapse formation. The molecular basis of lithium action is complex with various pathways involved in cross talk. Of these multiple pathways, we have focused on lithium induced inhibition of glycogen synthase kinase-3β, block of inositol phosphate pathway and up regulation of neurotrophins as there are direct evidences of involvement of these in lithium induced neuroplasticity. This review provides a bird’s eye view of studies that could provide insight into special aspect of lithium action, induction of plasticity, which have implication for treating a wide variety of neurological conditions
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
审稿时长
16 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信