松香苷对顺铂所致肾毒性的保护作用

Gitanjalee C. Shimpi, Pushparaj R. Patil
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引用次数: 0

摘要

玫瑰花青素是一种o -甲基化花青素,由花青素衍生而来。它是在玫瑰花中发现的一种色素,在玫瑰报春花中浓度较低。分子对接研究预测,松香苷具有足够的结构能力,使其成为治疗多种疾病的可行药物候选物。本研究旨在评价松香苷对顺铂所致大鼠肾毒性的肾保护作用。肾毒性是最严重的副作用。这种毒性是由自由基引起的。这种自由基损害肾小管,被罗辛丁克服。材料与方法:通过对动物进行口服急性毒性试验,评估其潜在毒性,结果表明其是安全的。同时给药顺铂25天,观察10、20 mg/kg的松香苷对大鼠肾脏的保护作用。测量了几种生化参数来支持酶和非酶氧化应激,如超氧化物歧化酶(SOD)、丙二醛(MDA)和谷胱甘肽过氧化物酶(GSH)。同样,一些非蛋白氮成分和血液化学参数的变化也支持了与化学诱导肾毒性发病机制相关的理论。结果:顺铂可引起生化、酶和血化学的显著变化,而松香苷可有效控制这些变化。结论:本研究将松香苷与肾保护作用联系起来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protective effect of Rosinidin on Cisplatin-Induced Nephrotoxicity
Rosinidin is an O-methylated anthocyanidin derived from Cyanidin. It is a pigment found in the flowers of Catharanthus roseus and, in lower concentration, in Primula rosea. The molecular docking studies predicted that rosinidin has adequate structural competency, making it a viable medicinal candidate for the treatment of a wide range of disorders. The current study intends to assess rosinidin nephroprotective efficacy against nephrotoxicity induced by cisplatin in rats. nephrptoxicity is most serious side effect. This toxicity caused by free radicals. This free radicals damage Renal Tubule which is overcome by Rosinidin. Materials and Methods: Oral acute toxicity tests of rosinidin were conducted to assess potential toxicity in animals, and it was shown to be safe. The nephroprotective effect of rosinidin 10, and 20 mg/kg were tested in rats for 25 days with concurrent administration of cisplatin. Several biochemical parameters were measured to support enzymatic and non-enzymatic oxidative stress such as superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH). Likewise, changes in several non-protein-nitrogenous components and blood chemistry parameters were made to support the theory linked with the pathogenesis of chemical-induced nephrotoxicity. Results: Cisplatin caused significant changes in biochemical, enzymatic, and blood chemistry, which rosinidin efficiently controlled. Conclusions: The present investigation linked rosinidin with nephroprotective efficacy in experimental models.
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