{"title":"P53通路与癌症:从实验到临床","authors":"Takashi Tokino, Masashi Idogawa, Yasushi Sasaki","doi":"10.1016/j.pmu.2015.03.003","DOIUrl":null,"url":null,"abstract":"<div><p>Next-generation sequencing has revealed the genomic landscapes of human cancers and has strengthened the claim that <em>TP53</em> is the most frequently mutated gene in human cancers. In this review, we intend to clarify the molecular mechanisms underlying the tumor suppressive functions of p53 and understand the involvement of the p53 signaling pathway in tumorigenesis. One of the major goals of this review is to guide the development of more effective approaches for reducing cancer prevalence and fatality.</p></div>","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"4 ","pages":"Pages 1-3"},"PeriodicalIF":0.0000,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pmu.2015.03.003","citationCount":"5","resultStr":"{\"title\":\"P53 pathway and cancer: From bench to clinic\",\"authors\":\"Takashi Tokino, Masashi Idogawa, Yasushi Sasaki\",\"doi\":\"10.1016/j.pmu.2015.03.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Next-generation sequencing has revealed the genomic landscapes of human cancers and has strengthened the claim that <em>TP53</em> is the most frequently mutated gene in human cancers. In this review, we intend to clarify the molecular mechanisms underlying the tumor suppressive functions of p53 and understand the involvement of the p53 signaling pathway in tumorigenesis. One of the major goals of this review is to guide the development of more effective approaches for reducing cancer prevalence and fatality.</p></div>\",\"PeriodicalId\":101009,\"journal\":{\"name\":\"Personalized Medicine Universe\",\"volume\":\"4 \",\"pages\":\"Pages 1-3\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.pmu.2015.03.003\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Personalized Medicine Universe\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2186495015000073\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Personalized Medicine Universe","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2186495015000073","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Next-generation sequencing has revealed the genomic landscapes of human cancers and has strengthened the claim that TP53 is the most frequently mutated gene in human cancers. In this review, we intend to clarify the molecular mechanisms underlying the tumor suppressive functions of p53 and understand the involvement of the p53 signaling pathway in tumorigenesis. One of the major goals of this review is to guide the development of more effective approaches for reducing cancer prevalence and fatality.
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