涉及自由基中间体的抗癌药物作用的分子机制

J. William Lown
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引用次数: 59

摘要

广泛讨论了临床有用的抗癌药物的作用机制,其中自由基中间体涉及其细胞毒性作用和/或代谢。此外,几个因素有助于药物代谢和激活和相互作用与大分子细胞靶标进行了讨论,因为他们涉及到自由基途径。还考虑了细胞保护酶在不同组织中抗氧化损伤的作用和水平,以及抗癌药物作用和毒性的临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular mechanisms of action of anticancer agents involving free radical intermediates

An extensive discussion is presented of the mechanisms of action of clinically useful anticancer agents in which free radical intermediates have been implicated in their cytotoxic action and/or metabolism. In addition the several factors contributing to drug metabolism and activation and interaction with macromolecular cell targets are discussed as they relate to free radical pathways. Consideration is also given to the action and levels in different tissues of cell protective enzymes against oxidative lesions and the clinicnal implication to anticancer drug action and toxicity.

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