利用纳米体扩展植物NLRs对不同病原体的识别光谱

IF 4.6 4区 农林科学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Ruyi Wang, Guo-Liang Wang, Yuese Ning
{"title":"利用纳米体扩展植物NLRs对不同病原体的识别光谱","authors":"Ruyi Wang,&nbsp;Guo-Liang Wang,&nbsp;Yuese Ning","doi":"10.1007/s42994-023-00111-x","DOIUrl":null,"url":null,"abstract":"<div><p>The strategy to expand the recognition spectrum of plant nucleotide-binding domain leucine-rich repeat (NLR) proteins by modifying their recognition sequences is generally limited and often unsuccessful. Kourelis et al. introduced a groundbreaking approach for generating a customized immune receptor, called Pikobody. This method involves integrating a nanobody domain of a fluorescent protein (FP) into a plant NLR. Their research demonstrates that the resulting Pikobody successfully initiates an immune response against diverse pathogens when exposed to the corresponding FP.</p></div>","PeriodicalId":53135,"journal":{"name":"aBIOTECH","volume":"4 3","pages":"272 - 276"},"PeriodicalIF":4.6000,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Harnessing nanobodies to expand the recognition spectrum of plant NLRs for diverse pathogens\",\"authors\":\"Ruyi Wang,&nbsp;Guo-Liang Wang,&nbsp;Yuese Ning\",\"doi\":\"10.1007/s42994-023-00111-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The strategy to expand the recognition spectrum of plant nucleotide-binding domain leucine-rich repeat (NLR) proteins by modifying their recognition sequences is generally limited and often unsuccessful. Kourelis et al. introduced a groundbreaking approach for generating a customized immune receptor, called Pikobody. This method involves integrating a nanobody domain of a fluorescent protein (FP) into a plant NLR. Their research demonstrates that the resulting Pikobody successfully initiates an immune response against diverse pathogens when exposed to the corresponding FP.</p></div>\",\"PeriodicalId\":53135,\"journal\":{\"name\":\"aBIOTECH\",\"volume\":\"4 3\",\"pages\":\"272 - 276\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2023-08-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"aBIOTECH\",\"FirstCategoryId\":\"1091\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s42994-023-00111-x\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"aBIOTECH","FirstCategoryId":"1091","ListUrlMain":"https://link.springer.com/article/10.1007/s42994-023-00111-x","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

通过修改植物核苷结合域富亮氨酸重复序列(NLR)蛋白的识别序列来扩大其识别谱的策略通常是有限的,而且往往不成功。Kourelis等人介绍了一种突破性的方法来产生定制的免疫受体,称为Pikobody。该方法涉及将荧光蛋白(FP)的纳米体结构域整合到植物NLR中。他们的研究表明,当暴露于相应的FP时,由此产生的Pikobody成功地启动了针对多种病原体的免疫反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Harnessing nanobodies to expand the recognition spectrum of plant NLRs for diverse pathogens

The strategy to expand the recognition spectrum of plant nucleotide-binding domain leucine-rich repeat (NLR) proteins by modifying their recognition sequences is generally limited and often unsuccessful. Kourelis et al. introduced a groundbreaking approach for generating a customized immune receptor, called Pikobody. This method involves integrating a nanobody domain of a fluorescent protein (FP) into a plant NLR. Their research demonstrates that the resulting Pikobody successfully initiates an immune response against diverse pathogens when exposed to the corresponding FP.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
7.70
自引率
2.80%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信