利用纳米体扩展植物NLRs对不同病原体的识别光谱

IF 4.6 4区 农林科学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Ruyi Wang, Guo-Liang Wang, Yuese Ning
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引用次数: 0

摘要

通过修改植物核苷结合域富亮氨酸重复序列(NLR)蛋白的识别序列来扩大其识别谱的策略通常是有限的,而且往往不成功。Kourelis等人介绍了一种突破性的方法来产生定制的免疫受体,称为Pikobody。该方法涉及将荧光蛋白(FP)的纳米体结构域整合到植物NLR中。他们的研究表明,当暴露于相应的FP时,由此产生的Pikobody成功地启动了针对多种病原体的免疫反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Harnessing nanobodies to expand the recognition spectrum of plant NLRs for diverse pathogens

The strategy to expand the recognition spectrum of plant nucleotide-binding domain leucine-rich repeat (NLR) proteins by modifying their recognition sequences is generally limited and often unsuccessful. Kourelis et al. introduced a groundbreaking approach for generating a customized immune receptor, called Pikobody. This method involves integrating a nanobody domain of a fluorescent protein (FP) into a plant NLR. Their research demonstrates that the resulting Pikobody successfully initiates an immune response against diverse pathogens when exposed to the corresponding FP.

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来源期刊
CiteScore
7.70
自引率
2.80%
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