Effect of Low Dose Type I Fish Collagen Peptides Combined or not with Silicon on Skin Aging Signs in Mature Women

Clinical signs of dermal atrophy and skin aging (including skin dryness, hypo/hyperpigmentation, diminished skin elasticity and firmness) are associated with a reduction and disorganization of collagen [1,2]. Major changes of photoaging occur in the dermis. In photoaging, a profound decrease in collagen, glycosaminoglycans and proteoglycans is observed combined with a degeneration of elastic fibres (elastosis) resulting in a rough leathery skin surface with fine and coarse wrinkles [3]. Scanning electron microscopic examination has shown that the number and width of collagen fibre bundles decreases with age [4]. Collagen, particularly Types 1 and 3 collagen, is the major structural protein present in human skin [5,6].