Liming HE , Zifang ZHAO , Mengke ZHANG , Zhijie XIANG , Kui HONG , Fengkai FAN , Yousheng CAI
{"title":"青霉异喹啉A:一种新的四氢异喹啉，来源于红树真菌青霉菌","authors":"Liming HE , Zifang ZHAO , Mengke ZHANG , Zhijie XIANG , Kui HONG , Fengkai FAN , Yousheng CAI","doi":"10.1016/S2707-3688(23)00046-8","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>This study aims to search for structurally novel, natural bioactive products from mangrove-derived fungi.</p></div><div><h3>Methods</h3><p>Compounds were isolated and purified by column chromatography on HP20 macroreticular resin, silica gel, Sephadex LH-20 gel, and high performance liquid chromatography. The structures of the isolates were analyzed using NMR and MS data, and the absolute configuration of <strong>1</strong> was determined by calculated ECD spectroscopic methods. The cytotoxicity of all the isolates was tested against HCT-116, HepG2, HEK 293t, and 5637 cancer cell lines using CCK-8 assay.</p></div><div><h3>Results</h3><p>A new tetrahydroisoquinoline named peniciisoquinoline A <strong>(1)</strong> was obtained from <em>Penicillium</em> sp. DM27 along with five known compounds. Peniciisoquinoline A <strong>(1)</strong> was inactive against the four cancer cell lines.</p></div><div><h3>Conclusion</h3><p>This study conducted chemical research on <em>Penicillium</em> sp. DM27 and tested the cytotoxic activity of the new alkaloid <strong>(1),</strong> which will assist in the further development and utilization of mangrove-derived fungi.</p></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"3 3","pages":"Pages 248-254"},"PeriodicalIF":0.0000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368823000468/pdfft?md5=750fee5096bb11e37d8a0bf7a0f1b6cb&pid=1-s2.0-S2707368823000468-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Peniciisoquinoline A: A new tetrahydroisoquinoline from mangrove-derived fungus Penicillium sp. DM27\",\"authors\":\"Liming HE , Zifang ZHAO , Mengke ZHANG , Zhijie XIANG , Kui HONG , Fengkai FAN , Yousheng CAI\",\"doi\":\"10.1016/S2707-3688(23)00046-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>This study aims to search for structurally novel, natural bioactive products from mangrove-derived fungi.</p></div><div><h3>Methods</h3><p>Compounds were isolated and purified by column chromatography on HP20 macroreticular resin, silica gel, Sephadex LH-20 gel, and high performance liquid chromatography. The structures of the isolates were analyzed using NMR and MS data, and the absolute configuration of <strong>1</strong> was determined by calculated ECD spectroscopic methods. The cytotoxicity of all the isolates was tested against HCT-116, HepG2, HEK 293t, and 5637 cancer cell lines using CCK-8 assay.</p></div><div><h3>Results</h3><p>A new tetrahydroisoquinoline named peniciisoquinoline A <strong>(1)</strong> was obtained from <em>Penicillium</em> sp. DM27 along with five known compounds. Peniciisoquinoline A <strong>(1)</strong> was inactive against the four cancer cell lines.</p></div><div><h3>Conclusion</h3><p>This study conducted chemical research on <em>Penicillium</em> sp. DM27 and tested the cytotoxic activity of the new alkaloid <strong>(1),</strong> which will assist in the further development and utilization of mangrove-derived fungi.</p></div>\",\"PeriodicalId\":100787,\"journal\":{\"name\":\"Journal of Holistic Integrative Pharmacy\",\"volume\":\"3 3\",\"pages\":\"Pages 248-254\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2707368823000468/pdfft?md5=750fee5096bb11e37d8a0bf7a0f1b6cb&pid=1-s2.0-S2707368823000468-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Holistic Integrative Pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2707368823000468\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Holistic Integrative Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2707368823000468","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Peniciisoquinoline A: A new tetrahydroisoquinoline from mangrove-derived fungus Penicillium sp. DM27
Objective
This study aims to search for structurally novel, natural bioactive products from mangrove-derived fungi.
Methods
Compounds were isolated and purified by column chromatography on HP20 macroreticular resin, silica gel, Sephadex LH-20 gel, and high performance liquid chromatography. The structures of the isolates were analyzed using NMR and MS data, and the absolute configuration of 1 was determined by calculated ECD spectroscopic methods. The cytotoxicity of all the isolates was tested against HCT-116, HepG2, HEK 293t, and 5637 cancer cell lines using CCK-8 assay.
Results
A new tetrahydroisoquinoline named peniciisoquinoline A (1) was obtained from Penicillium sp. DM27 along with five known compounds. Peniciisoquinoline A (1) was inactive against the four cancer cell lines.
Conclusion
This study conducted chemical research on Penicillium sp. DM27 and tested the cytotoxic activity of the new alkaloid (1), which will assist in the further development and utilization of mangrove-derived fungi.
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