Nur Özgedik Turhan, Özden Arisoy, Fatih Ulaş, Güler Buğdayci, Melek Altintaş Gülner
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The Hamilton Depression Rating Scale (HAM-D), The Clinical Global Impressions Scale (CGI) and Global Assessment of Functioning Scale (GAF) were used to assess disease severity.</p><p><strong>Results: </strong>CRP level and choroidal thickness in the major depression group were significantly higher than the healthy controls. Vitamin D level and the ganglion cell layer (GCL) volume was significantly lower in the major depression group compared to healthy controls. Positive correlation was found between HAM-D and CRP in major depressive patients; a negative correlation was found between current attack duration and GCL volume. CGI was positively correlated with CRP and HAM-D. GAS was negatively correlated with CRP and HAM-D.</p><p><strong>Conclusion: </strong>It has been shown that major depression might be an inflammatory disorder with possible degenerative processes observed with OCT and CRP measurements. 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引用次数: 0
摘要
导言最近的研究表明,抑郁症与炎症及其导致的血管/神经元损伤之间存在关系。在这项研究中,我们旨在使用光学相干断层扫描(OCT)这一无创成像方法,研究抑郁症和伴随的维生素 D 缺乏可能导致的炎症和退化:对 24 名健康对照组和 42 名未服药的重度抑郁症患者进行了维生素 D、C 反应蛋白(CRP)和 OCT 参数的比较。汉密尔顿抑郁评分量表(HAM-D)、临床总体印象量表(CGI)和总体功能评估量表(GAF)用于评估疾病的严重程度:结果:重度抑郁症组的 CRP 水平和脉络膜厚度明显高于健康对照组。重度抑郁症组的维生素 D 水平和神经节细胞层(GCL)体积明显低于健康对照组。重度抑郁症患者的 HAM-D 与 CRP 呈正相关;当前发作持续时间与 GCL 体积呈负相关。CGI 与 CRP 和 HAM-D 呈正相关。结论:结论:研究表明,重度抑郁症可能是一种炎症性疾病,通过 OCT 和 CRP 测量可以观察到可能的退化过程。但要证明因果关系,还需要进行纵向跟踪研究。
Vitamin D: An Overlooked Parameter in Studies of Depression Using Optic Coherence Tomography.
Introduction: The relationship between depression and inflammation and the resulting vascular/neuronal damage have been demonstrated in recent studies. In this study we aimed to investigate inflammation and the possible degeneration that can be caused by depression and accompanying vitamin D deficiency using a non-invasive imaging method of optical coherence tomography (OCT).
Methods: Twenty-four healthy controls and 42 drug free major depressive patients matched for age, sex and eye measurements were compared in terms of vitamin D, C Reactive Protein (CRP) and OCT parameters. The Hamilton Depression Rating Scale (HAM-D), The Clinical Global Impressions Scale (CGI) and Global Assessment of Functioning Scale (GAF) were used to assess disease severity.
Results: CRP level and choroidal thickness in the major depression group were significantly higher than the healthy controls. Vitamin D level and the ganglion cell layer (GCL) volume was significantly lower in the major depression group compared to healthy controls. Positive correlation was found between HAM-D and CRP in major depressive patients; a negative correlation was found between current attack duration and GCL volume. CGI was positively correlated with CRP and HAM-D. GAS was negatively correlated with CRP and HAM-D.
Conclusion: It has been shown that major depression might be an inflammatory disorder with possible degenerative processes observed with OCT and CRP measurements. But longitudinal follow up studies are needed to demonstrate a cause and effect relationship.
期刊介绍:
Archives of Neuropsychiatry (Arch Neuropsychiatry) is the official journal of the Turkish Neuropsychiatric Society. It is published quarterly, and four editions annually constitute a volume.
Archives of Neuropsychiatry is a peer reviewed scientific journal that publishes articles on psychiatry, neurology, and behavioural sciences. Both clinical and basic science contributions are welcomed. Submissions that address topics in the interface of neurology and psychiatry are encouraged. The content covers original research articles, reviews, letters to the editor, and case reports.