脑血流调节的集总参数模型

M. Olufsen, L. Lipsitz, A. Nadim
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引用次数: 0

摘要

脑血流的动态变化和伴随体位变化的相关血管反应,使大脑在低血压应激时维持灌注,目前尚不完全清楚。这项工作的目的是利用脑血流的集总参数模型来分析从坐姿到站立姿势变化过程中关键参数(全身和脑血管阻力)的变化。这样的模型揭示了血管对低血压应激的适应,并可能最终帮助确定在衰老、高血压和其他临床条件下发生的大脑自动调节的变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Lumped Parameter Model for Cerebral Blood Flow Regulation
Dynamic changes in cerebral blood flow and the associated vascular responses accompanying posture change that enable the brain to maintain perfusion during hypotensive stress are not fully understood. The aim of this work is to use a lumped parameter model of cerebral blood flow to analyze changes in key parameters (systemic and cerebrovascular resistances) during posture change from sitting to standing. Such a model sheds light on vascular adaptation to hypotensive stress, and could ultimately help determine the changes in cerebral autoregulation that occur in aging, hypertension, and other clinical conditions.
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