饲粮中添加金菊果肉对高脂饮食/链脲佐菌素诱导的糖尿病大鼠脑胆碱酯酶功能的影响

S. Akomolafe, S. Oyeleye, I. Odeniyi, Iyabo F. Oladapo, A. Akinyemi, F. Oyetayo, O. Ajayi
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摘要

流行病学研究表明,阿尔茨海默病与糖尿病有很强的相关性。这种情况发生的确切机制尚不清楚。然而,脑功能对葡萄糖的依赖被认为是一种可能的机制。因此,本研究探讨了高脂饮食/链脲佐菌素(STZ)诱导的糖尿病大鼠降糖作用的金菊果肉(CAPP)的神经保护作用。将动物分为对照组、STZ诱导组、STZ +二甲双胍(阳性对照组)、STZ + 5% CAPP、STZ + 10% CAPP、对照+ 5% CAPP和对照+ 10% CAPP 7个组,每组6只。在STZ诱导前分别饲喂正常饲粮(非糖尿病组)和高脂饲粮(糖尿病组)2周,分别饲喂含5%和10% CAPP的饲粮14 d。实验结束后测定大鼠脑胆碱酯酶及抗氧化活性。结果表明,与对照组相比,stz -糖尿病组的乙酰胆碱酯酶(AChE)、丁基胆碱酯酶(BuChE)、精氨酸酶、腺苷脱氨酶(ADA)和抗氧化活性均发生改变。AChE、BuChE、精氨酸酶和ADA活性显著降低(p < 0.05)。此外,与stz -糖尿病组相比,所有补充饮食组和二甲双胍治疗组的抗氧化剂水平也随之上升。总之,我们可以认为,水果果肉通过抗胆碱酯酶活性和改善大脑抗氧化状态来预防糖尿病大鼠的神经损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impacts of Dietary Chrysophyllum albidum Fruit Pulp on Brain Cholinesterase Function in High-Fat Diet/Streptozotocin-Induced Diabetic Rats
Epidemiologic studies have shown strong correlations between Alzheimer’s disease and diabetes mellitus. The exact mechanism through which this happens remains unclear. However, the dependence on glucose for brain function has been proposed as one possible mechanism. Hence, this study investigated the neuroprotective potential of Chrysophyllum albidum fruit pulp (CAPP) with hypoglycaemic properties in diabetic rats induced with high-fat diet/streptozotocin (STZ). The animals were grouped into seven units as follows: control, STZ-induced, STZ + metformin (positive control), STZ + 5% CAPP, STZ + 10% CAPP, control + 5% CAPP and control + 10% CAPP and each group was made up of six rats. The animals were first placed on normal diet (non-diabetic groups) and high fat diet (diabetic groups) for a fortnight, respectively before induction with STZ and were treated with diets containing 5 and 10% CAPP for 14 days. After the experiment, the rat brain cholinesterase and antioxidant activities were determined. The results revealed that acetylcholinesterase (AChE), butylcholinesterase (BuChE), arginase, adenosine deaminase (ADA) and antioxidant activities were altered in STZ-diabetic group in comparison to the control. However, a significant decrease at p < 0.05 was found in the activities of AChE, BuChE, arginase and ADA. In addition, there was a concomitant rise in the levels of antioxidant in all the groups administered supplemented diets and the group treated with metformin in comparison to the STZ-diabetic group. Conclusively, we can suggest that the fruit pulp prevents neurological damage in diabetic rats via anticholinesterase activity and improvement of brain antioxidant status.
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