耻骨骨髓炎:流行病学和治疗失败的相关因素

IF 5 Q3 Medicine

Medecine et maladies infectieuses Pub Date : 2020-11-01 DOI:10.1016/j.medmal.2019.10.012

A. Becker , C. Triffault-Fillit , F. Valour , L. Boussel , A. Ruffion , F. Laurent , E. Senneville , C. Chidiac , T. Ferry

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引用次数: 10

摘要

目的探讨耻骨骨髓炎(PO)的流行病学特点，探讨治疗失败的相关因素。方法回顾性研究根据初始治疗的结果:成功或失败来描述PO。通过单变量Cox分析确定与失败相关的因素。Kaplan-Meier曲线组间比较采用log-rank检验。结果纳入25例患者，随访13年;24%的PO有血源性感染。失败(44%)总是观察到慢性术后表现(76%)。瘘管(32%)仅在术后表现中观察到，并且与失败显著相关(HR 5.1;p = 0.011)。其他危险因素为盆腔恶性肿瘤病史、脓肿、广谱β -内酰胺酶产肠杆菌科感染和多微生物感染。结论po多为术后并发多微生物感染，复发风险高。在更大的队列研究中，可以评估更积极的手术策略对失败率高的患者的疗效。

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Pubic osteomyelitis: Epidemiology and factors associated with treatment failure

Objective

To describe the epidemiology of pubic osteomyelitis (PO) and to look for factors associated with treatment failure.

Method

Retrospective study describing PO according to outcome: success or failure of initial management. Factors associated with failure determined by univariate Cox analysis. Kaplan-Meier curve compared between groups by log-rank test.

Results

Twenty-five patients were included over a 13-year period; 24% of PO had blood-borne infection. Failure (44%) was always observed in chronic postoperative presentations (76%). Fistula (32%) was only observed in postoperative presentations and was significantly associated with failure (HR 5.1; P = 0.011). Other risk factors were pelvic malignant tumor history, abscess, infection due to extended-spectrum beta-lactamase-producing Enterobacteriaceae, and polymicrobial infection.

Conclusion

PO is most often a chronic postoperative polymicrobial infection in patients with comorbidities at high risk of relapse. Studies in larger cohorts could assess the efficacy of more aggressive surgical strategies in patients at high risk of failure.

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来源期刊

Medecine et maladies infectieuses 医学-传染病学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

10.7 weeks

期刊介绍： L''organe d''expression de la Société de Pathologie Infectieuse de Langue Française (SPILF). Médecine et Maladies Infectieuses is the official publication of the Société de Pathologie Infectieuse de Langue Française (SPILF). Médecine et Maladies Infectieuses is indexed in the major databases: Medline, Web of Science/Clarivate and Scopus. The journal publishes scientific /research articles, general reviews, short communications and letters, in both English and French. The journal welcomes submissions on the various aspects of infectious pathologies and pathogenic agents. Médecine et Maladies Infectieuses focuses on clinical therapeutics, nosocomial infections, biology, prevention, as well as epidemiology and therapeutics.