肿瘤标志物网络的数学建模

2015 International Conference on Biomedical Engineering and Computational Technologies (SIBIRCON) Pub Date : 2015-10-01 DOI:10.1109/SIBIRCON.2015.7361888

O. F. Voropaeva, Y. Shokin, L. M. Nepomnyaschchikh, S. R. Senchukova

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引用次数: 1

摘要

本文致力于对描述p53和Mdm2蛋白在相互作用中浓度动力学的方程组的解进行数值分析。对数学模型参数偏离基值时的解进行了详细的研究。在数值实验中，研究了系统的状态，如细胞不受控制的凋亡死亡的威胁，加速生物体的衰老过程以及过度抑制p53诱导的细胞凋亡，从而增加肿瘤的风险。详细研究了系统在应力条件下的管理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mathematical modeling of the tumor markers network

This paper is devoted to a numerical analysis of the solutions of the equations system describing the dynamics of the concentration of p53 and Mdm2 proteins in their interaction. A detailed study of the solutions was made when the mathematical model parameters deviated from the basal values. Within the numerical experiments, the states of the system, such as threat by the uncontrolled apoptotic death of cellules, accelerating the aging processes of organisms and of the excessive suppression of p53-induced apoptosis, which increases the risk of tumors, have been investigated. The mechanism of managing the system under stress conditions has been studied in detail.

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2015 International Conference on Biomedical Engineering and Computational Technologies (SIBIRCON)

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