利用波长为311 nm的窄带光疗(UVB -光谱)对局限性硬皮病患者进行复杂治疗的现代方法

T. Lytynska
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摘要

局限性硬皮病(LC)是一种慢性多因素疾病,其特征是长期、慢性、进行性病程,伴有连续的炎症、纤维化和萎缩阶段。LC (Morphea病)的相关性和医学-社会重要性不仅取决于该病患者数量的持续增加,还取决于该病临床表现的多样性、严重侵袭性病程的病例数量的增加、诊断的错误以及缺乏有效的治疗方法。目的:将波长为311 nm的窄带光疗(uvb谱)纳入综合治疗,提高各种临床形式LC (Morfea病)患者的治疗效果。材料和方法。对42例LC(斑块和线状)、外阴硬缩性地衣和特发性帕兹尼-皮里尼萎缩性萎缩皮病进行了检查和治疗。治疗效果的评价以患者的治疗结果为基础,随机分为两组。主组患者在基础治疗的基础上给予波长为311 nm的窄带光疗(UVB光谱)。对照组患者给予基础治疗。结果和讨论。由于主组患者的综合治疗,11例(32.6%)患者明显改善,14例(41.2%)患者改善,9例(26.5%)患者病情稳定。在对照组患者中,2例(25%)患者病情改善,3例(37.5%)患者病情稳定,3例(37.5%)患者保持负动力并进一步进展。在疗程结束后的12个月内,主组患者中有11.8%的患者复发,而对照组为63%。结论。在复合治疗中纳入波长为311 nm的窄带光疗(UVB-spectrum),可提高治疗效果,减少各种临床形式LC患者的复发频率。在LC的复杂治疗中,使用波长为311 nm的窄带光疗(uvb光谱)在住院和门诊都是可能的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Modern approaches to complex treatment of patients with localized scleroderma using narrow­band phototherapy (UVB­­-spectrum) with a wave length of 311 nm
Localizeds cleroderma (LC) is a chronic multifactorial disease characterized by a long, chronic, progressive course with successive stages of inflammation, fibrosis, and atrophy. The relevance and medico-social importance of LC (Morphea disease) is determined not only by the permanent increase in the number of patients with this pathology, but also by the variety of clinical manifestations of the disease, the increase in the number of cases of a severe aggressive course, errors in diagnosis, and the lack of effective treatment methods.Objective — to increase the effectiveness of treatment of patients with various clinical forms of LC (Morfea’s disease) by including narrow-band phototherapy (UVB-spectrum) with a wave length of 311 nm into complex therapy. Materials and methods. 42 patients with LC (plaque and linear forms), extragenital scleroatrophic lichen and idiopathic Pazini—Pierini atrophoderma) were examined and treated. The evaluation of therapy effectiveness was based on the results of treatment of patients who were randomly divided into two clinical groups. The patients of the main group were prescribed narrow-band phototherapy (UVB spectrum) with a wavelength of 311 nm against the background of basic therapy. The patients of the comparison group were given basic therapy. Results and discussion. As a result of the complex treatment of patients in the main group, significant improvement was observed in 11 (32.6 %), improvement in 14 (41.2 %), stabilization of the process in 9 (26.5 %). In the patients of the comparison group, improvement was noted in 2 (25 %), stabilization of the process — in 3 (37.5 %), preservation of the negative dynamics and further progression of the process — in 3 (37.5 %). Within 12 months after the end of the course of treatment, relapses of the disease were observed in 11.8 % of patients of the main group against 63 % of people in the comparison group. Conclusions. The inclusion of narrow-band phototherapy (UVB-spectrum) with a wavelength of 311 nm in complex therapy increases the effectiveness of treatment and reduces the frequency of relapses in patients with various clinical forms of LC.The use of narrow-band phototherapy (UVB-spectrum) with a wave length of 311 nm in the complex therapy of LC is possible both in inpatient and outpatient settings.
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