甲氨蝶呤毒性的抢救治疗:1例报告

Shruthi Suresh, Namratha C. Manjunath, S. Kumar B C
{"title":"甲氨蝶呤毒性的抢救治疗:1例报告","authors":"Shruthi Suresh, Namratha C. Manjunath, S. Kumar B C","doi":"10.18203/issn.2455-4529.intjresdermatol20232549","DOIUrl":null,"url":null,"abstract":"Methotrexate (MTX) is widely used for the treatment of psoriasis. It has an antiproliferative action by inhibiting dihydrofolate reductase enzyme, therefore interferes with folic acid synthesis. MTX toxicity is rarely reported and the most common cause of it is accidental overdosage by the patient. This is a case report of a 51-year-old male, a known case of psoriasis, who presented with multiple erythematous tender plaques associated with burning sensation. He self-medicated with tablet MTX 5 mg daily for 10 days when the lesions got exacerbated and was found to be leucopenic. On skin biopsy, diagnosis of psoriasis with MTX induced epidermal necrolysis was established. Patient was treated with filgrastim 300 μg which was given subcutaneously 1 day apart. On follow up, lesions subsided and repeat counts were within normal limits. Patients should be explained about the selected treatment regime and discouraged from self-medicating.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"330 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rescue therapy in methotrexate toxicity: case report\",\"authors\":\"Shruthi Suresh, Namratha C. Manjunath, S. Kumar B C\",\"doi\":\"10.18203/issn.2455-4529.intjresdermatol20232549\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Methotrexate (MTX) is widely used for the treatment of psoriasis. It has an antiproliferative action by inhibiting dihydrofolate reductase enzyme, therefore interferes with folic acid synthesis. MTX toxicity is rarely reported and the most common cause of it is accidental overdosage by the patient. This is a case report of a 51-year-old male, a known case of psoriasis, who presented with multiple erythematous tender plaques associated with burning sensation. He self-medicated with tablet MTX 5 mg daily for 10 days when the lesions got exacerbated and was found to be leucopenic. On skin biopsy, diagnosis of psoriasis with MTX induced epidermal necrolysis was established. Patient was treated with filgrastim 300 μg which was given subcutaneously 1 day apart. On follow up, lesions subsided and repeat counts were within normal limits. Patients should be explained about the selected treatment regime and discouraged from self-medicating.\",\"PeriodicalId\":14331,\"journal\":{\"name\":\"International Journal of Research in Dermatology\",\"volume\":\"330 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Research in Dermatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232549\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Research in Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232549","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

甲氨蝶呤(MTX)被广泛用于治疗牛皮癣。它通过抑制二氢叶酸还原酶具有抗增殖作用,从而干扰叶酸的合成。MTX毒性很少报道,最常见的原因是患者意外过量服用。这是一例51岁男性牛皮癣患者的病例报告,他表现为多发红斑性压痛斑块并伴有烧灼感。当病变加重并发现白细胞减少时,他自行服用MTX片剂,每天5毫克,持续10天。皮肤活检,诊断银屑病与甲氨蝶呤诱导表皮坏死松解。患者给予非格拉西汀300 μg,每隔1天皮下给药。在随访中,病变消退,重复计数在正常范围内。应向患者解释所选择的治疗方案,不鼓励患者自行用药。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rescue therapy in methotrexate toxicity: case report
Methotrexate (MTX) is widely used for the treatment of psoriasis. It has an antiproliferative action by inhibiting dihydrofolate reductase enzyme, therefore interferes with folic acid synthesis. MTX toxicity is rarely reported and the most common cause of it is accidental overdosage by the patient. This is a case report of a 51-year-old male, a known case of psoriasis, who presented with multiple erythematous tender plaques associated with burning sensation. He self-medicated with tablet MTX 5 mg daily for 10 days when the lesions got exacerbated and was found to be leucopenic. On skin biopsy, diagnosis of psoriasis with MTX induced epidermal necrolysis was established. Patient was treated with filgrastim 300 μg which was given subcutaneously 1 day apart. On follow up, lesions subsided and repeat counts were within normal limits. Patients should be explained about the selected treatment regime and discouraged from self-medicating.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信