亨丽埃塔·拉克斯不朽的一生

Faroque A Khan
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引用次数: 18

摘要

1951)是一个贫穷的南部非洲裔烟草农民,他的宫颈癌肿瘤是马里兰州巴尔的摩市约翰霍普金斯大学的乔治·奥托·盖培养的细胞的来源。这些“不朽”的细胞在她去世60年后仍然“活着”,给医学研究带来了革命性的变化。在她2010年出版的《亨丽埃塔·拉克斯不朽的一生》一书中,丽贝卡·斯克卢特记录了拉克斯细胞系(为了保护她的身份,以她的姓和名的前两个字母命名,被称为海拉细胞系)和拉克斯家族的历史。亨丽埃塔的丈夫大卫·拉克斯(David Lacks)在她去世后几乎没有得到任何消息。当时在南方盛行的种族问题引发的猜疑,再加上阶级和教育问题。拉克斯家族的成员一直对组织系的存在一无所知,当迈克尔·罗杰斯(Michael Rogers) 1976年在《滚石》(Rolling Stone)杂志上发表的一篇文章披露了组织系的存在时,家人感到困惑的是,亨丽埃塔的细胞怎么可能在未经同意的情况下被取出,在她去世25年后,细胞怎么还活着。斯克卢特的书带领读者踏上了一段不可思议的旅程,从20世纪50年代约翰霍普金斯医院的“有色人种”病房,到摆满海拉细胞的研究实验室,再到亨丽埃塔位于弗吉尼亚州的垂死小镇克拉弗,再到亨丽埃塔的子孙们居住的巴尔的摩东部。关于亨丽埃塔·拉克斯故事的基本事实是有据可查的。1951年2月1日,拉克斯来到约翰霍普金斯医院,因为她的子宫颈有一个痛苦的“结”,阴道有血。活检后,她被诊断出患有宫颈癌。这个肿瘤的外观与检查的妇科医生霍华德·琼斯医生所见过的任何东西都不一样。在治疗癌症之前,在她不知情或未经允许的情况下,从肿瘤中取出细胞用于研究,这是当时的标准程序。八天后,乔治·奥托·盖医生在她的第二次就诊时,获得了她的另一个肿瘤样本。这些细胞最终成为HeLa的不朽细胞系。8月8日,拉克斯在剧烈疼痛和病情没有好转的情况下回到约翰霍普金斯医院,要求住院治疗,直到10月4日去世,享年31岁。随后的部分尸检显示,癌症已经转移到她的全身。Gey“发现(Henrietta的)细胞做了一些他们以前从未见过的事情:它们可以被保存……
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Immortal Life of Henrietta Lacks
1951) was a poor Southern African-American tobacco farmer whose cancerous cervical tumor was the source of cells George Otto Gey at Johns Hopkins in Baltimore, Maryland, cultured. These " immortal " cells remain " alive, " 60 years after her death, revolutionizing medical research. In her 2010 book, The Immortal Life of Henrietta Lacks, Rebecca Skloot documents the histories of both the cell line—called the HeLa cell line after the first two letters of her first and last names to protect her identity—and the Lacks family. Henrietta's husband , David Lacks, was told little following her death. Suspicions fueled by racial issues prevalent in the South at the time were compounded by issues of class and education. Members of the Lacks family were kept in the dark about the existence of the tissue line, and when its existence was revealed in a 1976 Rolling Stone article by Michael Rogers, family members were confused about how Henrietta's cells could have been taken without consent and how they could still be alive 25 years after her death. Skloot's book takes the reader on an incredible journey from the " colored " ward of Johns Hopkins Hospital in the 1950s to the research laboratories with freezers full of HeLa cells, to Henrietta's small, dying town of Clover, Virginia, to east Baltimore, where Henrietta's children and grandchildren live. The basic facts about the story of Henrietta Lacks are well documented. On February 1, 1951, Ms. Lacks visited Johns Hopkins because of a painful " knot " in her cervix and bloody vaginal discharge. After a biopsy, she was diagnosed with cervical cancer. The appearance of the tumor was unlike anything the examining gynecologist, Dr. Howard Jones, had seen. Prior to the treatment for the carcinoma, cells from the tumor were removed for research purposes without her knowledge or permission, which was standard procedure at that time. During her second visit eight days later, Dr. George Otto Gey obtained another sample of her tumor. These cells would eventually become the HeLa immortal cell line. In significant pain and without improvement, Lacks returned to Johns Hopkins Hospital on August 8 demanding admission and remained there until her death on October 4 at the age of 31. A subsequent partial autopsy showed that the cancer had metastasized throughout her body. Gey " discovered that [Henrietta's] cells did something they had never seen before: They could be kept …
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