双平行序列进展作为血管对肿瘤坏死和胶质母细胞瘤细胞增殖的伪反应

L. Agius
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引用次数: 0

摘要

胶质母细胞瘤生物学的定向预测包括病变浸润的构成性克隆,就其确定的潜在增殖涉及主要低分化细胞群而言。在很大程度上,包容性参数与不同类型遗传病变的存在相关,例如,p53突变与肿瘤细胞中表皮生长因子受体(EGFR)扩增/过表达的含义。演变中的胶质母细胞瘤的多灶性血管的浸润和强烈的血管化强调了与肿瘤坏死的多灶性的独特联系。协同特征还包括由白质内高度活跃的浸润灶过程引起的明显的伪多灶性倾向。肿瘤干细胞被认为是胶质瘤的增殖细胞成分,可能不同于胶质瘤起始细胞,负责肿瘤的建立和存活。治疗耐药可能与肿瘤中少量发现的胶质瘤干细胞的耐药有关。患者的年龄是胶质母细胞瘤的一个显著特征,其进展与相邻束(如胼胝体)的肿瘤细胞浸润血管形成密切平行,也与一侧或两侧大脑半球的脑白质密切平行。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dual Parallel Sequence Progression as Vascular Pseudo-Reactivities to Tumor Necrosis and to Proliferation of Glioblastoma Cells
Directional projections of glioblastoma biology include the constitutive clonality of a lesion that infiltrates in terms of its established potential proliferation involving predominantly poorly differentiated cell populations. In large measure, inclusive parameters correlate with the presence of contrastingly different types of genetic lesion, such as for example, the implication of p53 mutation versus the amplification/over-expression of the Epidermal Growth Factor Receptor (EGFR) in the neoplastic cells. Involvement of vasculature and of intense vascularization of multiple foci of the evolving glioblastoma emphasizes the distinctive link to multiple foci of tumor necrosis. Collaborative features include also an apparent propensity for pseudo-multifocality arising from processes of highly active foci of infiltration within the white matter. Cancer stem cells are believed to be the propagating cell component in gliomas and may differ from glioma initiating cells responsible for the establishment and survival of the neoplasm. Therapeutic resistance may specifically relate to resistance of the glioma stem cells that are found in small numbers in the tumor. Patient age is a distinctive feature of glioblastoma that progresses in close parallel with the vasculogenesis in neoplastic cell infiltration of adjacent tracts such as the corpus callosum and also the cerebral white matter of one or both cerebral hemispheres.
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