干扰素- γ在肺结核中的治疗潜力

IF 3.4 Q2 CHEMISTRY, MEDICINAL

ADMET and DMPK Pub Date : 2022-01-14 DOI:10.5599/admet.1078

S. Berns, J. Isakova, Polina Pekhtereva

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引用次数: 2

摘要

结核病是世界范围内严重的健康问题之一。寻找改善结核病治疗结果和克服耐药性的方法在于了解感染过程发展的发病机制。干扰素系统，特别是干扰素- γ的作用，已被确定为结核病免疫反应的主要环节。自上世纪末以来，人们一直在临床试验中研究和评价干扰素- γ的临床疗效。有证据表明干扰素- γ作为复合治疗的一部分具有临床疗效。最近的实验数据使人们有可能考虑干扰素- γ作为治疗耐多药结核病的一种有希望的治疗选择，作为值得进一步研究的复杂治疗的一部分。

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Therapeutic potential of interferon-gamma in tuberculosis

Tuberculosis is one of the critical health problems worldwide. The search for ways to improve the results of tuberculosis treatment and overcome drug resistance lies in understanding the pathogenesis of the development of the infectious process. The interferon system, particularly the role of interferon-gamma, has been identified as the main link in the immune response in tuberculosis. The clinical efficacy of interferon-gamma has been studied and evaluated in clinical trials since the end of the last century. There was obtained evidence of the clinical efficacy of interferon-gamma as part of complex therapy. Recent experimental data make it possible to consider interferon-gamma as a promising therapeutic option for the treatment of multidrug-resistant tuberculosis as part of complex therapy worthy of further studies.

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来源期刊

ADMET and DMPK Multiple-

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： ADMET and DMPK is an open access journal devoted to the rapid dissemination of new and original scientific results in all areas of absorption, distribution, metabolism, excretion, toxicology and pharmacokinetics of drugs. ADMET and DMPK publishes the following types of contributions: - Original research papers - Feature articles - Review articles - Short communications and Notes - Letters to Editors - Book reviews The scope of the Journal involves, but is not limited to, the following areas: - physico-chemical properties of drugs and methods of their determination - drug permeabilities - drug absorption - drug-drug, drug-protein, drug-membrane and drug-DNA interactions - chemical stability and degradations of drugs - instrumental methods in ADMET - drug metablic processes - routes of administration and excretion of drug - pharmacokinetic/pharmacodynamic study - quantitative structure activity/property relationship - ADME/PK modelling - Toxicology screening - Transporter identification and study