IL-10和TNF-?伊拉克的T1DM患者。

IF 1.3 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Biomedical Research-tokyo Pub Date : 2021-01-01 DOI:10.35841/0970-938X.32.3.75-75

Sabreen Ali Mezil, R. Al-Shawk

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引用次数: 0

摘要

肿瘤坏死因子(TNF-α)也被称为分化因子，是炎症和免疫反应的关键成分。TNF-α是一种多效性促炎细胞因子，由活化的巨噬细胞和淋巴细胞对感染、炎症和环境应激反应产生。TNF-α已被证明在导致1型糖尿病患者β细胞死亡的自身免疫级联反应中发挥作用，并且反复抗体介导的TNF-α作用抑制已被证明可保护非肥胖小鼠免于β细胞死亡。在这项研究中，我们试图证明在患有不同糖尿病病程的15岁以下儿童和青少年中，促炎和抗炎细胞因子包括IL-10和TNF-α之间的相关性，它们都参与了T1D的发病机制。

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Estimation level of IL-10 and TNF-? in Iraq T1DM patient.

Tumor Necrosis Factor (TNF-α) also known as differentiation factor, is a key component in inflammatory and immune responses. TNF-α is a pleiotropic proinflammatory cytokine produced in response to infection, inflammation, and environmental stressors by activated macrophages, and lymphocytes. TNF-α has been shown to play a part in the autoimmune cascade that leads to beta cell death in type 1 diabetes, and repeated antibodymediated TNF-α action inhibition has been shown to protect non-obese mice from beta cell death. We tried to demonstrate a correlation between pro-inflammatory and anti-inflammatory cytokines including IL-10 and TNF-α, which are both involved in the pathogenesis of T1D, in children and adolescents under the age of 15 with varying diabetes durations in this study.

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来源期刊

Biomedical Research-tokyo 医学-医学：研究与实验

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biomedical Research is peer-reviewed International Research Journal . It was first launched in 1990 as a biannual English Journal and later became triannual. From 2008 it is published in Jan-Apr/ May-Aug/ Sep-Dec..