分子网络中的调控元件

IF 7.9 Q1 Medicine

Wiley Interdisciplinary Reviews-Systems Biology and Medicine Pub Date : 2017-01-01 DOI:10.1002/wsbm.1374

A. Doane, O. Elemento

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引用次数: 16

摘要

调控元件决定分子网络的连通性，并介导从DNA环到转录、转录后和翻译后调控的各种调控过程。这篇综述强调了我们目前对分子网络中发现的不同类型的调控元件的理解，重点是DNA调控元件。我们强调了在全基因组范围内绘制调控元件的技术进步和当前的挑战，并描述了通过从大型基因组数据集重建调控网络来发现这些元件的新计算方法。中国生物医学工程学报，2017,32(1):444 - 444。doi: 10.1002 / wsbm.1374

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Regulatory elements in molecular networks

Regulatory elements determine the connectivity of molecular networks and mediate a variety of regulatory processes ranging from DNA looping to transcriptional, posttranscriptional, and posttranslational regulation. This review highlights our current understanding of the different types of regulatory elements found in molecular networks with a focus on DNA regulatory elements. We highlight technical advances and current challenges for the mapping of regulatory elements at the genome‐wide scale, and describe new computational methods to uncover these elements via reconstructing regulatory networks from large genomic datasets. WIREs Syst Biol Med 2017, 9:e1374. doi: 10.1002/wsbm.1374

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来源期刊

Wiley Interdisciplinary Reviews-Systems Biology and Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

18.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine