{"title":"[重症急性胰腺炎患者血浆d -二聚体变化及其预后意义]。","authors":"Hong-jun Wu, Rongqing Li, Yi Li, Xue-zhong Yu","doi":"10.3760/CMA.J.ISSN.1003-0603.2012.11.006","DOIUrl":null,"url":null,"abstract":"OBJECTIVE\nTo study the role of plasma D-dimer in human severe acute pancreatitis (SAP) and its relationship with disease severity.\n\n\nMETHODS\nA prospective study was performed. From February 2010 to June 2011, plasma concentration of D-dimer and the results of other routine laboratory tests were measured in 32 SAP inpatients at admission immediately and 24, 48, 72 hours after admission. Ranson scores were also recorded. The relationship between plasma concentration of D-dimer and the results of other routine laboratory tests, Ranson scores were analyzed, and so did the relationship between plasma concentration of D-dimer and severity of patient's condition.\n\n\nRESULTS\n(1) There were no obvious changes for plasma concentration of D-dimer and the results of other routine laboratory index in 32 SAP inpatients at each time points after admission. (2) Plasma concentration of D-dimer of SAP was positively related to white blood count (WBC), creatinine (Cr), prothrombin time (PT) and activated partial thromboplastin time (APTT) and negatively related to hematocrit (Hct), albumin and calcium (P<0.05 or P<0.01). Plasma concentration of D-dimer of SAP at 48 hours after admission had positive relationship with Ranson scores (r=0.729, P=0.001). (3) Plasma concentration of D-dimer of SAP inpatients in CT grade D, E stage were significantly higher than that in CT grade B, C stage (1.18±0.02 mg/L, 1.23±0.01 mg/L vs. 0.90±0.02 mg/L, 0.93±0.01 mg/L, all P<0.05). (4) Plasma concentration of D-dimer of SAP in inpatients with multiple organ failure (MOF) at 24 hours and 48 hours were significantly higher than that in inpatients without MOF (24 hours: 1.26±0.02 mg/L vs. 0.93±0.02 mg/L, 48 hours:1.25±0.02 mg/L vs. 0.93±0.02 mg/L, both P<0.05).\n\n\nCONCLUSION\nPlasma concentration of the D-dimer is significantly increased in SAP patients, and is related to the severity. The first plasma concentration of D-dimer of SAP after admission can well reflect severity of patient's condition.","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"37 1","pages":"658-61"},"PeriodicalIF":0.0000,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"[Plasma D-dimer changes and prognostic implication in severe acute pancreatitis].\",\"authors\":\"Hong-jun Wu, Rongqing Li, Yi Li, Xue-zhong Yu\",\"doi\":\"10.3760/CMA.J.ISSN.1003-0603.2012.11.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"OBJECTIVE\\nTo study the role of plasma D-dimer in human severe acute pancreatitis (SAP) and its relationship with disease severity.\\n\\n\\nMETHODS\\nA prospective study was performed. From February 2010 to June 2011, plasma concentration of D-dimer and the results of other routine laboratory tests were measured in 32 SAP inpatients at admission immediately and 24, 48, 72 hours after admission. Ranson scores were also recorded. The relationship between plasma concentration of D-dimer and the results of other routine laboratory tests, Ranson scores were analyzed, and so did the relationship between plasma concentration of D-dimer and severity of patient's condition.\\n\\n\\nRESULTS\\n(1) There were no obvious changes for plasma concentration of D-dimer and the results of other routine laboratory index in 32 SAP inpatients at each time points after admission. (2) Plasma concentration of D-dimer of SAP was positively related to white blood count (WBC), creatinine (Cr), prothrombin time (PT) and activated partial thromboplastin time (APTT) and negatively related to hematocrit (Hct), albumin and calcium (P<0.05 or P<0.01). Plasma concentration of D-dimer of SAP at 48 hours after admission had positive relationship with Ranson scores (r=0.729, P=0.001). (3) Plasma concentration of D-dimer of SAP inpatients in CT grade D, E stage were significantly higher than that in CT grade B, C stage (1.18±0.02 mg/L, 1.23±0.01 mg/L vs. 0.90±0.02 mg/L, 0.93±0.01 mg/L, all P<0.05). (4) Plasma concentration of D-dimer of SAP in inpatients with multiple organ failure (MOF) at 24 hours and 48 hours were significantly higher than that in inpatients without MOF (24 hours: 1.26±0.02 mg/L vs. 0.93±0.02 mg/L, 48 hours:1.25±0.02 mg/L vs. 0.93±0.02 mg/L, both P<0.05).\\n\\n\\nCONCLUSION\\nPlasma concentration of the D-dimer is significantly increased in SAP patients, and is related to the severity. The first plasma concentration of D-dimer of SAP after admission can well reflect severity of patient's condition.\",\"PeriodicalId\":23992,\"journal\":{\"name\":\"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue\",\"volume\":\"37 1\",\"pages\":\"658-61\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1003-0603.2012.11.006\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1003-0603.2012.11.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
摘要
目的探讨血浆d -二聚体在重症急性胰腺炎(SAP)中的作用及其与病情严重程度的关系。方法采用前瞻性研究。2010年2月至2011年6月，测定32例SAP住院患者入院时及入院后24、48、72 h血浆d -二聚体浓度及其他常规实验室检查结果。Ranson评分也被记录下来。分析血浆d -二聚体浓度与其他常规实验室检查结果、Ranson评分的关系以及血浆d -二聚体浓度与患者病情严重程度的关系。结果(1)32例SAP住院患者入院后各时间点血浆d -二聚体浓度及其他常规实验室指标均无明显变化。(2) SAP血浆d -二聚体浓度与白细胞计数(WBC)、肌酐(Cr)、凝血酶原时间(PT)、活化部分凝血活素时间(APTT)呈正相关，与血细胞比容(Hct)、白蛋白、钙呈负相关(P<0.05或P<0.01)。入院后48 h血浆SAP d -二聚体浓度与Ranson评分呈正相关(r=0.729, P=0.001)。(3) SAP患者CT分级D、E期血浆D-二聚体浓度显著高于CT分级B、C期(1.18±0.02 mg/L、1.23±0.01 mg/L vs. 0.90±0.02 mg/L、0.93±0.01 mg/L, P均<0.05)。(4)住院多器官功能衰竭患者24小时、48小时血浆SAP d -二聚体浓度显著高于非多器官功能衰竭患者(24小时:1.26±0.02 mg/L vs. 0.93±0.02 mg/L, 48小时:1.25±0.02 mg/L vs. 0.93±0.02 mg/L, P均<0.05)。结论SAP患者血浆d -二聚体浓度明显升高，且与病情严重程度相关。入院后第一次血浆SAP d -二聚体浓度可以很好地反映患者病情的严重程度。
[Plasma D-dimer changes and prognostic implication in severe acute pancreatitis].
OBJECTIVE
To study the role of plasma D-dimer in human severe acute pancreatitis (SAP) and its relationship with disease severity.
METHODS
A prospective study was performed. From February 2010 to June 2011, plasma concentration of D-dimer and the results of other routine laboratory tests were measured in 32 SAP inpatients at admission immediately and 24, 48, 72 hours after admission. Ranson scores were also recorded. The relationship between plasma concentration of D-dimer and the results of other routine laboratory tests, Ranson scores were analyzed, and so did the relationship between plasma concentration of D-dimer and severity of patient's condition.
RESULTS
(1) There were no obvious changes for plasma concentration of D-dimer and the results of other routine laboratory index in 32 SAP inpatients at each time points after admission. (2) Plasma concentration of D-dimer of SAP was positively related to white blood count (WBC), creatinine (Cr), prothrombin time (PT) and activated partial thromboplastin time (APTT) and negatively related to hematocrit (Hct), albumin and calcium (P<0.05 or P<0.01). Plasma concentration of D-dimer of SAP at 48 hours after admission had positive relationship with Ranson scores (r=0.729, P=0.001). (3) Plasma concentration of D-dimer of SAP inpatients in CT grade D, E stage were significantly higher than that in CT grade B, C stage (1.18±0.02 mg/L, 1.23±0.01 mg/L vs. 0.90±0.02 mg/L, 0.93±0.01 mg/L, all P<0.05). (4) Plasma concentration of D-dimer of SAP in inpatients with multiple organ failure (MOF) at 24 hours and 48 hours were significantly higher than that in inpatients without MOF (24 hours: 1.26±0.02 mg/L vs. 0.93±0.02 mg/L, 48 hours:1.25±0.02 mg/L vs. 0.93±0.02 mg/L, both P<0.05).
CONCLUSION
Plasma concentration of the D-dimer is significantly increased in SAP patients, and is related to the severity. The first plasma concentration of D-dimer of SAP after admission can well reflect severity of patient's condition.
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