Study of the influence of peptide bioregulators on the resistance of the organism to adverse effects

The article is devoted to the prospects of using peptide bioregulators-cytomedins to increase the body's resistance to adverse environmental influences. Scientific publications on the general mechanisms of action of peptide bioregulators, the main clinical effects and applications, the results of studying their activity in individuals with signs of asthenia and reduced immunoreactivity under conditions of hypoxia, hyperthermia, exposure to aviation and space flight factors, deep-sea diving, and a complex of factors of the Arctic zone were analyzed. It has been shown that under the conditions of a single intranasal administration in low doses, the use of cortexin, epithalamin, thymogen and prostatilen contributes to an increase in the tolerance of adverse effects, and their short course use is characterized by the presence of delayed positive effects, reflecting the effect of drugs on the level of nonspecific resistance of the organism. The specific features of the action of individual drugs depend on the type of adverse effect and the organ tropism of the drug.