年轻女性心血管疾病患者下丘脑-垂体-肾上腺轴和下丘脑-垂体-性腺轴的功能状况

IF 0.2 Q4 SPORT SCIENCES
E. Milashechkina, T. Dzhandarova
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引用次数: 0

摘要

的目标。本文旨在评价女性血管张力障碍患者的下丘脑-垂体-肾上腺皮质系统和下丘脑-垂体-性腺系统的功能状况。材料和方法。该研究将一年级女学生分为三组:1组(对照组,n = 45) -表面健康的学生;2(实验,n = 27) -患有血管张力障碍(VVD)的特殊医疗组学生:第一个实验(n = 12) -诊断为高血压型VVD的学生,第二个实验(n = 15) -诊断为低张力型VVD的学生。通过唾液中皮质醇(K)、睾酮(T)和雌二醇(E)的浓度及E / T比值反映下丘脑-垂体-肾上腺皮质和下丘脑-垂体-性腺系统的功能状态。结果。两组VVD女性唾液中皮质醇含量均显著高于对照组(P < 0.001, P < 0.05)。女性高血压性VVD患者的皮质醇水平高于低渗性VVD患者(P < 0.05)。低渗型VVD女性患者雌二醇水平比对照组高24%,高血压型VVD女性患者雌二醇水平比对照组高2倍以上。两组患者睾酮水平均显著高于对照组(P < 0.001),女性高血压型VVD患者睾酮水平明显升高。两组VVD学生的E/T比与对照组相比无显著变化。女性高血压型VVD与低渗型VVD的差异有统计学意义(P < 0.01)。结论。研究结果表明,激素分泌的变化可被认为是心血管系统调节机制中维持机体自我调节、保证应激适应的一系列紧密相连的反应。因此,任何环节的中断都需要使用身体的储备能力,这影响了主要适应系统的性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
THE FUNCTIONAL STATUS OF HYPOTHALAMIC-PITUITARY-ADRENAL AND HYPOTHALAMIC-PITUITARY-GONADAL AXIS IN YOUNG WOMEN WITH CARDIOVASCULAR DISEASE
Aim. The article aims to evaluate the functional status of the hypothalamic-pituitary-adrenocortical and hypothalamic-pituitary-gonadal systems in females with vascular dystonia from a special medical group. Materials and methods. The study involved first-year female students divided into 3 groups: 1 (control, n = 45) – apparently healthy students; 2 (experimental, n = 27) – students from a special medical group with vascular dystonia (VVD): 1st experimental (n = 12) – students diagnosed with VVD of the hypertensive type, 2nd experimental (n = 15) – students with VVD of the hypotonic type. The functional status of the hypothalamic-pituitaryadrenocortical and hypothalamic-pituitary-gonadal systems was revealed by the concentration of cortisol (K), testosterone (T) and estradiol (E) in saliva and the E / T ratio. Results. The content of cortisol in saliva in females with VVD in both experimental groups was significantly higher (P < 0.001, P < 0.05) than in the control group. Cortisol levels are higher in females with hypertensive VVD than in females with hypotonic VVD (P < 0.05). In females with VVD of the hypotonic type, the level of estradiol is higher by 24% than in the control group, and in females with VVD of the hypertensive type, estradiol is more than twice higher. The concentration of testosterone was significantly higher in both experimental groups compared to the control group (P < 0.001), an increase in T was observed in females with VVD of the hypertensive type. The E/T ratio in students with VVD in both groups showed no significant changes compared to the control group. Significant positive differences were revealed in females with VVD of the hypertensive type compared with VVD of the hypotonic type (P < 0.01). Conclusion. The results of the study showed that changes in hormone secretion can be considered as a chain of closely connected reactions in the regulatory mechanisms of the cardiovascular system for maintaining self-regulation of the body and ensuring adaptation under stress. Therefore, the disruption of any link requires the use of reserve capacities of the body, which affects the performance of the leading adaptation systems.
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来源期刊
Human Sport Medicine
Human Sport Medicine SPORT SCIENCES-
CiteScore
0.70
自引率
50.00%
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