赤霉素酸对硫代乙酰胺致sd大鼠急性肝毒性的影响

Haytham Mohamedelfatih Mohamed Makki
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引用次数: 4

摘要

赤霉素(Gibberellic acid, GBA)是一种天然的植物生长激素,控制着许多植物发育过程。为探讨GBA对硫代乙酰胺(TAA)致急性肝毒性的保护作用,将30只雄性SD大鼠随机分为6组(5只/组);正常对照组(NC):每os (p.o)接收蒸馏水(DW),仅GBA:接收GBA (20 mg/kg, p.o), TAA:接收DW和TAA (350 mg/kg, i.p), GBA 5:接收GBA (5 mg/kg, p.o)和TAA (350 mg/kg, i.p), GBA 10:接收GBA (10 mg/kg, p.o)和TAA (350 mg/kg, i.p), GBA 20:接收GBA (20 mg/kg, p.o)和TAA (350 mg/kg, i.p)。采集血液和血浆进行生化分析,采集肝组织保存用于组织学分析。与NC相比,taa引起的肝酶、低血糖、缺氧、红细胞增多症和代谢性酸中毒明显增加,证实了taa引起的急性肝毒性。然而,taa中毒大鼠GBA预处理显示其肝保护作用,显著降低肝酶水平,并以剂量依赖的方式减轻肝脏病变
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Gibberellic Acid on Thioacetamide-Induced Acute Liver Toxicity in Sprague-Dawley Rats
Gibberellic acid (GBA) is a natural plant growth hormone, controlling many developmental processes. In order to explore the protective effects of GBA against Thioacetamide (TAA)-induced acute liver toxicity, thirty male Sprague-Dawley (SD) rats were randomly allocated into six groups (5 rats/group); Normal control (NC): received distilled water (DW) per os (p.o.), GBA only: received (20 mg/kg, p.o.) of GBA, TAA: received DW and TAA (350 mg/kg, i.p.), GBA 5: received GBA (5 mg/kg, p.o.) and TAA (350 mg/kg, i.p.), GBA 10: received GBA (10 mg/kg, p.o.) and TAA (350 mg/kg, i.p.), and GBA 20: received GBA (20 mg/kg, p.o.) and TAA (350 mg/kg, i.p.). Blood and plasma were collected for biochemical analysis while liver tissues were harvested and preserved for histological analysis. The results confirmed the TAA-induced acute liver toxicity by the significantly increased liver enzymes, hypoglycemia, hypoxia, polycythemia, and metabolic acidosis as compared with NC. However, pretreatment of TAA-intoxicated rats with GBA indicated the hepatoprotective effects by reducing liver enzyme levels significantly and alleviating hepatic lesions in a dose-dependent manner
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