基于极外一致性条件的回顾性呼吸门控系统

Q4 Biochemistry, Genetics and Molecular Biology
Maosen Lian, Yi Li, Xiaohui Gu, Shouhua Luo
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引用次数: 0

摘要

由于小鼠自由呼吸时快速的呼吸速率和呼吸位移,在体内成像的运动伪影是微计算机断层扫描(micro- ct)的主要挑战。呼吸门控通常用于投影图像采集或单投影定性,以消除体内运动带来的伪影。本文提出了一种新的呼吸门控方法,该方法首先将一个旋转周期划分为若干段,并根据ep极一致性条件(ep极一致性条件,ECC)的值从当前段的投影图像序列中提取呼吸信号,然后根据测量到的平均呼吸周期,设置下一段的启动时间和龙门架的旋转速度进行呼吸相位同步,以此循环往复。门控过程是通过三个周期的整个投影,每个角度的三个投影中只有一个符合其相位值,并保留以供将来用于层析图像重建。在实际实验中,分别采用基于ECC的门控方法和传统的硬件门控方法对C57BL/6小鼠进行微CT成像。结果表明,与基于硬件的方法相比,该方法不仅在投影图像上获得了更好的一致性,而且更有效地抑制了活体小鼠乳房、腹部和头部等不同部位的条纹伪影。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Retrospective Respiratory Gating System Based on Epipolar Consistency Conditions
: Motion artifacts of in vivo imaging, due to rapid respiration rate and respiration displacements of the mice while free-breathing, is a major challenge in micro computed tomography(micro-CT). The respiratory gating is often served for either projective images acquisition or per projection qualification, so as to eliminate the artifacts brought by in vivo motion. In this paper, we propose a novel respiratory gating method, which firstly divides one rotation cycle into a number of segments, and extracts the respiratory signal from the projective image series of current segment by the value of the epipolar consistency conditions (ECC), then in terms of the measured average respiratory period, sets next segment’s start-up time and rotation speed of the gantry for respiratory phase synchronization, and so on so forth. The gating procedure is through the whole projections of three cycles, only one among three projections at each angle is qualified by their phase value and is retained for future use for tomographic image reconstruction. In practical experiment, the ECC based gating method and the conventional hardware gating method are employed on micro CT imaging of C57BL/6 mice respectively. The result shows that, compared with the hardware based one, the proposed method not only achieve much better consistency in the projection images, but also suppresses the streak artifacts more effectively on the different parts like the breast, abdomen and head of in vivo mice.
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来源期刊
Molecular & Cellular Biomechanics
Molecular & Cellular Biomechanics CELL BIOLOGYENGINEERING, BIOMEDICAL&-ENGINEERING, BIOMEDICAL
CiteScore
1.70
自引率
0.00%
发文量
21
期刊介绍: The field of biomechanics concerns with motion, deformation, and forces in biological systems. With the explosive progress in molecular biology, genomic engineering, bioimaging, and nanotechnology, there will be an ever-increasing generation of knowledge and information concerning the mechanobiology of genes, proteins, cells, tissues, and organs. Such information will bring new diagnostic tools, new therapeutic approaches, and new knowledge on ourselves and our interactions with our environment. It becomes apparent that biomechanics focusing on molecules, cells as well as tissues and organs is an important aspect of modern biomedical sciences. The aims of this journal are to facilitate the studies of the mechanics of biomolecules (including proteins, genes, cytoskeletons, etc.), cells (and their interactions with extracellular matrix), tissues and organs, the development of relevant advanced mathematical methods, and the discovery of biological secrets. As science concerns only with relative truth, we seek ideas that are state-of-the-art, which may be controversial, but stimulate and promote new ideas, new techniques, and new applications.
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