体外模拟真实骨样条件的旋转支架最佳设计参数的确定:流体结构相互作用研究

Abhisek Gupta, Masud Rana, N. Mondal
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引用次数: 0

摘要

为了获得骨组织工程仿生支架,需要合适的支架结构。为此,对不同的micro - ct(µct)和陀螺仪进行了流固耦合分析,观察了流体流动对体外力学响应的影响。采用计算流体力学方法对支架的渗透性和壁面剪应力进行了计算,然后采用有限元方法对支架内部的机械应力进行了计算。根据单元胞数和孔隙率设计了不同类型的陀螺仪,其中陀螺仪的孔隙率与微ct相同。该研究的主要目的是研究不同陀螺仪和微ct的渗透率、WSS和机械应力与单位细胞数量和孔隙率的变化。还比较了陀螺仪和微ct的力学响应。本研究结果表明,微ct的渗透率和WSS接近于具有8个单位细胞的陀螺仪,但在机械应力方面存在显著差异。陀螺仪的渗透性随孔隙率的增加而增加,但随胞数的增加而降低。陀螺仪内的WSS则呈现相反的趋势。本研究将指导我们预测理想的骨小梁置换支架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Determination Of Optimum Design Parameters For Gyroid Scaffolds To Mimic A Real Bone-Like Condition In Vitro: A Fluid Structure Interaction Study
A suitable scaffold architecture is always desirable to get a biomimetic scaffold for bone tissue engineering. In this regard, a fluid structure interaction analysis was carried out on different Micro-CTs (µCTs) and gyroids to observe the in vitro mechanical responses due to fluid flow. Computational fluid dynamics method was used to evaluate the permeability and wall shear stress (WSS), followed by a finite element method to obtain the mechanical stress within scaffolds. Different types of gyroids were designed based on the number of unit cells and porosity, where porosity of gyroids was kept same as µCTs. The main objective of the study is to examine the variations of permeability, WSS and mechanical stress with respect to the number of unit cells and porosity for different gyroids and µCTs. Mechanical responses were also compared between gyroids and µCTs. The results of this study highlighted that permeability and WSS of µCTs came close to the gyroids with 8 unit cells but had significant differences in mechanical stress. The permeability of gyroids increased with the increase of porosity but decreased with the increase in number of unit cells. The opposite trend was shown in case of WSS within gyroids. This study will guide us in predicting an ideal scaffold for trabecular bone replacement.
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