Vera Alexandrovna Abramova, Nikolai Nikolaevich Belyaev
{"title":"高血糖会改变胸腺上皮细胞的功能","authors":"Vera Alexandrovna Abramova, Nikolai Nikolaevich Belyaev","doi":"10.1016/j.jmhi.2013.04.001","DOIUrl":null,"url":null,"abstract":"<div><p>Insulin-dependent diabetes mellitus (IDDM) is considered to be a consequence of unchecked auto-immune processes. Alterations in immune system responses are thought to be the cause of the disease, but the possibility that altered metabolite levels (glucose) can establish the disease by specifically acting on and altering thymus stroma functions has not been investigated. Therefore, the direct effect of hyperglycaemia (HG) on central tolerance mechanisms as a causative agent needs to be investigated.</p></div>","PeriodicalId":100803,"journal":{"name":"Journal of Medical Hypotheses and Ideas","volume":"7 2","pages":"Pages 65-68"},"PeriodicalIF":0.0000,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jmhi.2013.04.001","citationCount":"0","resultStr":"{\"title\":\"Hyperglycaemia alters thymic epithelial cell function\",\"authors\":\"Vera Alexandrovna Abramova, Nikolai Nikolaevich Belyaev\",\"doi\":\"10.1016/j.jmhi.2013.04.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Insulin-dependent diabetes mellitus (IDDM) is considered to be a consequence of unchecked auto-immune processes. Alterations in immune system responses are thought to be the cause of the disease, but the possibility that altered metabolite levels (glucose) can establish the disease by specifically acting on and altering thymus stroma functions has not been investigated. Therefore, the direct effect of hyperglycaemia (HG) on central tolerance mechanisms as a causative agent needs to be investigated.</p></div>\",\"PeriodicalId\":100803,\"journal\":{\"name\":\"Journal of Medical Hypotheses and Ideas\",\"volume\":\"7 2\",\"pages\":\"Pages 65-68\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jmhi.2013.04.001\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medical Hypotheses and Ideas\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2251729413000116\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Hypotheses and Ideas","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2251729413000116","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Hyperglycaemia alters thymic epithelial cell function
Insulin-dependent diabetes mellitus (IDDM) is considered to be a consequence of unchecked auto-immune processes. Alterations in immune system responses are thought to be the cause of the disease, but the possibility that altered metabolite levels (glucose) can establish the disease by specifically acting on and altering thymus stroma functions has not been investigated. Therefore, the direct effect of hyperglycaemia (HG) on central tolerance mechanisms as a causative agent needs to be investigated.
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