微/纳米气泡超声诊断和治疗的新策略

R. Suzuki, Y. Oda, D. Omata, Y. Sawaguchi, M. Seki, Hitoshi Uruga, Tomoyuki Naoi, Y. Negishi, K. Maruyama
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引用次数: 1

摘要

治疗学是诊断学和治疗学相结合的新概念。在诊断领域,常用到各种医疗设备,如x射线计算机断层扫描、磁共振成像、正电子发射断层扫描和超声检查。由于这些不同设备的物理能量,超声波是一种有用的治疗工具,特别适用于超声诊断和癌症的热疗治疗。近年来,微泡被认为是一种有效的肿瘤血流显像剂。特别是索那唑,这是一种市售的微泡,已被用于肝肿瘤的检测。此外,微泡是治疗学的有用工具,因为它们不仅可以用作超声造影剂,还可以用作治疗超声热疗的增强剂。为了提高微泡在深层组织中的可及性,研究人员正在开发各种类型的小气泡,如亚微米大小的纳米气泡。我们还开发了新型脂质体气泡(泡脂质体),它由包裹在脂质双分子层中的全氟丙烷气体组成。与现有技术相比,气泡脂质体具有许多优点,如可作为超声显像剂,易于修饰其表面的靶向分子,并且非常适用于治疗性超声增强热疗。总之,超声波和微/纳米气泡的结合将为非侵入性治疗提供一种理想的方法。本文将介绍近年来利用微泡和纳米泡(如气泡脂质体)进行超声治疗的研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Novel Strategies for Ultrasound Diagnostics and Therapeutics by Micro/Nanobubbles
Theranostics is a novel concept that combines diagnostics and therapeutics. In the field of diagnostics, various pieces of medical equipment are commonly used, such as X-ray computed tomography,magnetic resonance imaging,positron emission tomography,and sonography. Because of physical energy within these different pieces of equipment,ultrasound is a useful tool for theranostics,and it is particularly suitable for diagnostics with sonography and therapeutics with hyperthermia for cancer. Recently,microbubbles were recognized as an effective type of agent for imaging blood flow in tumors. In particular,Sonazoid,which is a commercially available microbubble,has been used for detection of hepatic tumors. In addition,microbubbles are useful tools for theranostics because they can be used not only as an ultrasound contrast imaging agent but also as an enhancer for hyperthermia with therapeutic ultrasound. To improve the accessibility of microbubbles in the deep tissue,researchers are developing various types of smaller bubbles such as the submicron-sized nanobubble. We have also developed novel liposomal bubbles(Bubble liposomes),which consist of entrapped perfluoropropane gas in a lipid bilayer. Bubble liposomes have several advantages over existing technologies,such as they can be used as ultrasound imaging agents,it is easy to modify the targeting molecules on their surfaces,and they are highly applicable for the enhancement of hyperthermia with therapeutic ultrasound. In summary,the combination of ultrasound and micro/nanobubbles would allow for the development of an ideal method for noninvasive theranostics. In this review, we will introduce recent developments on ultrasound theranostics using microbubbles and nanobubbles such as Bubble liposomes.
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