Analytical Techniques Using ICP-MS for Clinical and Biological Analysis

Abstract : This article reviews recent analytical techniques using inductively coupled plasma-mass spectrometry (ICP-MS)immunoassay for clinical and bio analysis. We classified the techniques into two categories, direct and indirect analysis, whichdepend upon a guideline of whether tagging materials are used or not. Direct analysis is well known, and generally used in con-junction with various other techniques, such as laser ablation, chromatographic separations, etc. Recently, indirect analysis u singtagging elements has intensively been discussed because of its importance in future applications to bio and clinical analysis,including environmental and food industries. The method has shown advantages of multiplex detection, excellent sensitivity, andshort analysis time owing to signal amplification and magnetic separation. Now, it expands the application field from small bio-molecules to large cells.Keywords : ICP-MS, Nanoparticle, Immunoassay, Particle tagging Introduction Inductively coupled plasma mass spectrometry (ICP-MS) is one of the most commonly used analyticalinstruments for metal detection in various fields owing toits noteworthy features, including high sensitivity to tracelevel elements, good linear dynamic range, multiplexdetection, and low detection limits.