{"title":"PRISM:一种分析哺乳动物蛋白质组的新策略","authors":"Thomas Kislinger , Brian Cox , Andrew Emili","doi":"10.1016/S1741-8372(04)02422-3","DOIUrl":null,"url":null,"abstract":"<div><p><span>Advances in microcapillary </span>liquid chromatography tandem mass spectrometry<span> (LC–MS/MS), in combination with the completion of genome sequencing projects, have opened the door to systematic large-scale mammalian protein expression<span> profiling. The aim of this emerging field is to gain insight into the systems biology of complex multicellular organisms. A recently developed multistep analytical strategy, called PRISM (proteome investigation strategy for mammals), is a promising technology platform for investigating the complex proteome of mammalian tissues.</span></span></p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 2","pages":"Pages 37-42"},"PeriodicalIF":0.0000,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02422-3","citationCount":"0","resultStr":"{\"title\":\"PRISM: a new strategy to analyze the mammalian proteome\",\"authors\":\"Thomas Kislinger , Brian Cox , Andrew Emili\",\"doi\":\"10.1016/S1741-8372(04)02422-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Advances in microcapillary </span>liquid chromatography tandem mass spectrometry<span> (LC–MS/MS), in combination with the completion of genome sequencing projects, have opened the door to systematic large-scale mammalian protein expression<span> profiling. The aim of this emerging field is to gain insight into the systems biology of complex multicellular organisms. A recently developed multistep analytical strategy, called PRISM (proteome investigation strategy for mammals), is a promising technology platform for investigating the complex proteome of mammalian tissues.</span></span></p></div>\",\"PeriodicalId\":100382,\"journal\":{\"name\":\"Drug Discovery Today: TARGETS\",\"volume\":\"3 2\",\"pages\":\"Pages 37-42\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02422-3\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Discovery Today: TARGETS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1741837204024223\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today: TARGETS","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1741837204024223","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
微毛细管液相色谱串联质谱(LC-MS /MS)技术的进步，加上基因组测序项目的完成，为系统的大规模哺乳动物蛋白表达谱分析打开了大门。这个新兴领域的目标是深入了解复杂的多细胞生物的系统生物学。PRISM (proteome investigation strategy for mammals，哺乳动物蛋白质组研究策略)是研究哺乳动物组织复杂蛋白质组的一个很有前途的技术平台。
PRISM: a new strategy to analyze the mammalian proteome
Advances in microcapillary liquid chromatography tandem mass spectrometry (LC–MS/MS), in combination with the completion of genome sequencing projects, have opened the door to systematic large-scale mammalian protein expression profiling. The aim of this emerging field is to gain insight into the systems biology of complex multicellular organisms. A recently developed multistep analytical strategy, called PRISM (proteome investigation strategy for mammals), is a promising technology platform for investigating the complex proteome of mammalian tissues.
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