通络糖泰方对链脲霉素(STZ)疼痛性糖尿病周围神经病变模型大鼠血清疼痛物质5-HT、B-EP、组胺和缓激肽的影响

IF 1.3 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Biomedical Research-tokyo Pub Date : 2018-01-01 DOI:10.4066/biomedicalresearch.29-17-3167

Liu Haizhen, Zheng Guanlin, Zhu Xianghua, Wang Cailing, C. Shihong

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引用次数: 0

摘要

目的:探讨通络糖台汤对疼痛相关性糖尿病神经病变STZ大鼠血清5-羟色胺、β-EP、组胺和缓激肽的影响。方法:采用STZ腹腔注射大鼠糖尿病周围神经病变模型。将大鼠分为对照组、模型组、通络糖组和苯妥英组。每日给予生理盐水、通络糖泰或苯妥英钠，分别于3、5、9 w后测定各组大鼠血清中5-HT、β-EP、组胺和缓激肽水平。结果:药物干预3、5、9 w后，模型组5-HT、组胺和缓激肽水平均显著高于对照组(P<0.05)， β-EP水平显著降低。与模型组比较，通桃汤泰组和苯妥英组大鼠组胺和缓激肽含量均显著降低，β-EP水平显著降低。与苯妥英组比较，通桃酸泰组和苯妥英组大鼠组胺和缓激肽含量均显著降低，β-EP水平显著降低。结论:通桃糖台汤能显著降低stz诱导的糖尿病神经病变模型大鼠5-HT、组胺和缓激肽水平，增加β-EP含量，并具有明显的镇痛作用。

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Effects of Tongluotangtai recipe on serum pain substances 5-HT, B-EP, histamine and bradykinin in rats with painful diabetic peripheral neuropathy model of streptozotocin (STZ)

Objective: To investigate the effect of Tongluotangtai decoction on 5-HT, β-EP, histamine and bradykinin in serum of STZ rats with pain-related diabetic neuropathy. Methods: The rat model of diabetic peripheral neuropathy was made by intraperitoneal injection of STZ. The rats were divided into control group, model group, Tongluo sugar group and phenytoin. The rats were administrated with saline, Tongluo sugar Thai or phenytoin sodium daily, and the levels of 5- HT, β-EP, histamine and bradykinin in the serum of each group were measured after 3 w, 5 w and 9 w. Results: After 3 w, 5 w and 9 w of drug intervention, the levels of 5-HT, histamine and bradykinin in the model group were significantly higher than those in the control group (P<0.05) and the level of β-EP was significantly reduced. Compared with the model group, the contents of histamine and bradykinin in Tongtao Tangtai group and phenytoin group were significantly decreased and the level of β-EP was significantly reduced. Compared with the rats in the phenytoin group, the contents of histamine and bradykinin in Tongtao Suantai group and phenytoin group were significantly decreased and the level of β-EP was significantly reduced. Conclusion: Tongtao Tangtai decoction can significantly reduce the level of 5-HT, histamine and bradykinin in STZ-induced diabetic neuropathy model rats, increase the content of β-EP and exert a significant anti-pain effect.

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来源期刊

Biomedical Research-tokyo 医学-医学：研究与实验

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biomedical Research is peer-reviewed International Research Journal . It was first launched in 1990 as a biannual English Journal and later became triannual. From 2008 it is published in Jan-Apr/ May-Aug/ Sep-Dec..