通络糖泰方对链脲霉素(STZ)疼痛性糖尿病周围神经病变模型大鼠血清疼痛物质5-HT、B-EP、组胺和缓激肽的影响

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Liu Haizhen, Zheng Guanlin, Zhu Xianghua, Wang Cailing, C. Shihong
{"title":"通络糖泰方对链脲霉素(STZ)疼痛性糖尿病周围神经病变模型大鼠血清疼痛物质5-HT、B-EP、组胺和缓激肽的影响","authors":"Liu Haizhen, Zheng Guanlin, Zhu Xianghua, Wang Cailing, C. Shihong","doi":"10.4066/biomedicalresearch.29-17-3167","DOIUrl":null,"url":null,"abstract":"Objective: To investigate the effect of Tongluotangtai decoction on 5-HT, β-EP, histamine and bradykinin in serum of STZ rats with pain-related diabetic neuropathy. Methods: The rat model of diabetic peripheral neuropathy was made by intraperitoneal injection of STZ. The rats were divided into control group, model group, Tongluo sugar group and phenytoin. The rats were administrated with saline, Tongluo sugar Thai or phenytoin sodium daily, and the levels of 5- HT, β-EP, histamine and bradykinin in the serum of each group were measured after 3 w, 5 w and 9 w. Results: After 3 w, 5 w and 9 w of drug intervention, the levels of 5-HT, histamine and bradykinin in the model group were significantly higher than those in the control group (P<0.05) and the level of β-EP was significantly reduced. Compared with the model group, the contents of histamine and bradykinin in Tongtao Tangtai group and phenytoin group were significantly decreased and the level of β-EP was significantly reduced. Compared with the rats in the phenytoin group, the contents of histamine and bradykinin in Tongtao Suantai group and phenytoin group were significantly decreased and the level of β-EP was significantly reduced. Conclusion: Tongtao Tangtai decoction can significantly reduce the level of 5-HT, histamine and bradykinin in STZ-induced diabetic neuropathy model rats, increase the content of β-EP and exert a significant anti-pain effect.","PeriodicalId":9138,"journal":{"name":"Biomedical Research-tokyo","volume":"53 1","pages":"933-937"},"PeriodicalIF":1.3000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Tongluotangtai recipe on serum pain substances 5-HT, B-EP, histamine and bradykinin in rats with painful diabetic peripheral neuropathy model of streptozotocin (STZ)\",\"authors\":\"Liu Haizhen, Zheng Guanlin, Zhu Xianghua, Wang Cailing, C. Shihong\",\"doi\":\"10.4066/biomedicalresearch.29-17-3167\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To investigate the effect of Tongluotangtai decoction on 5-HT, β-EP, histamine and bradykinin in serum of STZ rats with pain-related diabetic neuropathy. Methods: The rat model of diabetic peripheral neuropathy was made by intraperitoneal injection of STZ. The rats were divided into control group, model group, Tongluo sugar group and phenytoin. The rats were administrated with saline, Tongluo sugar Thai or phenytoin sodium daily, and the levels of 5- HT, β-EP, histamine and bradykinin in the serum of each group were measured after 3 w, 5 w and 9 w. Results: After 3 w, 5 w and 9 w of drug intervention, the levels of 5-HT, histamine and bradykinin in the model group were significantly higher than those in the control group (P<0.05) and the level of β-EP was significantly reduced. Compared with the model group, the contents of histamine and bradykinin in Tongtao Tangtai group and phenytoin group were significantly decreased and the level of β-EP was significantly reduced. Compared with the rats in the phenytoin group, the contents of histamine and bradykinin in Tongtao Suantai group and phenytoin group were significantly decreased and the level of β-EP was significantly reduced. Conclusion: Tongtao Tangtai decoction can significantly reduce the level of 5-HT, histamine and bradykinin in STZ-induced diabetic neuropathy model rats, increase the content of β-EP and exert a significant anti-pain effect.\",\"PeriodicalId\":9138,\"journal\":{\"name\":\"Biomedical Research-tokyo\",\"volume\":\"53 1\",\"pages\":\"933-937\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical Research-tokyo\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4066/biomedicalresearch.29-17-3167\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Research-tokyo","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4066/biomedicalresearch.29-17-3167","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0

摘要

目的:探讨通络糖台汤对疼痛相关性糖尿病神经病变STZ大鼠血清5-羟色胺、β-EP、组胺和缓激肽的影响。方法:采用STZ腹腔注射大鼠糖尿病周围神经病变模型。将大鼠分为对照组、模型组、通络糖组和苯妥英组。每日给予生理盐水、通络糖泰或苯妥英钠,分别于3、5、9 w后测定各组大鼠血清中5-HT、β-EP、组胺和缓激肽水平。结果:药物干预3、5、9 w后,模型组5-HT、组胺和缓激肽水平均显著高于对照组(P<0.05), β-EP水平显著降低。与模型组比较,通桃汤泰组和苯妥英组大鼠组胺和缓激肽含量均显著降低,β-EP水平显著降低。与苯妥英组比较,通桃酸泰组和苯妥英组大鼠组胺和缓激肽含量均显著降低,β-EP水平显著降低。结论:通桃糖台汤能显著降低stz诱导的糖尿病神经病变模型大鼠5-HT、组胺和缓激肽水平,增加β-EP含量,并具有明显的镇痛作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Tongluotangtai recipe on serum pain substances 5-HT, B-EP, histamine and bradykinin in rats with painful diabetic peripheral neuropathy model of streptozotocin (STZ)
Objective: To investigate the effect of Tongluotangtai decoction on 5-HT, β-EP, histamine and bradykinin in serum of STZ rats with pain-related diabetic neuropathy. Methods: The rat model of diabetic peripheral neuropathy was made by intraperitoneal injection of STZ. The rats were divided into control group, model group, Tongluo sugar group and phenytoin. The rats were administrated with saline, Tongluo sugar Thai or phenytoin sodium daily, and the levels of 5- HT, β-EP, histamine and bradykinin in the serum of each group were measured after 3 w, 5 w and 9 w. Results: After 3 w, 5 w and 9 w of drug intervention, the levels of 5-HT, histamine and bradykinin in the model group were significantly higher than those in the control group (P<0.05) and the level of β-EP was significantly reduced. Compared with the model group, the contents of histamine and bradykinin in Tongtao Tangtai group and phenytoin group were significantly decreased and the level of β-EP was significantly reduced. Compared with the rats in the phenytoin group, the contents of histamine and bradykinin in Tongtao Suantai group and phenytoin group were significantly decreased and the level of β-EP was significantly reduced. Conclusion: Tongtao Tangtai decoction can significantly reduce the level of 5-HT, histamine and bradykinin in STZ-induced diabetic neuropathy model rats, increase the content of β-EP and exert a significant anti-pain effect.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Biomedical Research-tokyo
Biomedical Research-tokyo 医学-医学:研究与实验
CiteScore
2.40
自引率
0.00%
发文量
19
审稿时长
>12 weeks
期刊介绍: Biomedical Research is peer-reviewed International Research Journal . It was first launched in 1990 as a biannual English Journal and later became triannual. From 2008 it is published in Jan-Apr/ May-Aug/ Sep-Dec..
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信