线粒体动力学:在运动生理学和肌肉质量调节中的作用

IF 2.5 Q2 PHYSIOLOGY
Andre Djalalvandi , Luca Scorrano
{"title":"线粒体动力学:在运动生理学和肌肉质量调节中的作用","authors":"Andre Djalalvandi ,&nbsp;Luca Scorrano","doi":"10.1016/j.cophys.2022.100550","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>How mitochondria alter their morphology to meet cellular demands epitomizes the ‘form follows function’ architectural principle. These remodeling events are collectively termed ‘mitochondrial dynamics’. The influence of mitochondrial dynamics and of the mitochondria-shaping proteins that control it on skeletal muscle physiology has become clearer. </span>Endurance exercise prompts mitochondrial morphological changes that augment the respiratory capacity of the worked muscles. Mechanistically, exercise training increases </span>mitochondrial fusion<span> protein levels in skeletal muscle to promote the development of a hyperfused mitochondrial network that possesses denser cristae. Conversely, disruptions to the mitochondrial network through imbalances in mitochondrial dynamics lead to muscle atrophy. Insight into the connection between mitochondrial morphology and muscle-mass maintenance will help to pinpoint therapeutic targets that can be exploited to counteract sarcopenia and muscle atrophy in pathological conditions.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Mitochondrial dynamics: roles in exercise physiology and muscle mass regulation\",\"authors\":\"Andre Djalalvandi ,&nbsp;Luca Scorrano\",\"doi\":\"10.1016/j.cophys.2022.100550\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>How mitochondria alter their morphology to meet cellular demands epitomizes the ‘form follows function’ architectural principle. These remodeling events are collectively termed ‘mitochondrial dynamics’. The influence of mitochondrial dynamics and of the mitochondria-shaping proteins that control it on skeletal muscle physiology has become clearer. </span>Endurance exercise prompts mitochondrial morphological changes that augment the respiratory capacity of the worked muscles. Mechanistically, exercise training increases </span>mitochondrial fusion<span> protein levels in skeletal muscle to promote the development of a hyperfused mitochondrial network that possesses denser cristae. Conversely, disruptions to the mitochondrial network through imbalances in mitochondrial dynamics lead to muscle atrophy. Insight into the connection between mitochondrial morphology and muscle-mass maintenance will help to pinpoint therapeutic targets that can be exploited to counteract sarcopenia and muscle atrophy in pathological conditions.</span></p></div>\",\"PeriodicalId\":52156,\"journal\":{\"name\":\"Current Opinion in Physiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2022-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468867322000682\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468867322000682","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 2

摘要

线粒体如何改变其形态以满足细胞需求,体现了“形式服从功能”的建筑原则。这些重塑事件统称为“线粒体动力学”。线粒体动力学和控制它的线粒体形成蛋白对骨骼肌生理的影响已经变得更加清楚。耐力运动促进线粒体形态的改变,增强了运动肌肉的呼吸能力。从机制上讲,运动训练增加骨骼肌中线粒体融合蛋白的水平,促进具有更致密嵴的高灌注线粒体网络的发展。相反,线粒体动力学失衡对线粒体网络的破坏会导致肌肉萎缩。深入了解线粒体形态和肌肉质量维持之间的联系将有助于确定治疗靶点,这些靶点可以用来对抗病理状态下的肌肉减少症和肌肉萎缩。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mitochondrial dynamics: roles in exercise physiology and muscle mass regulation

How mitochondria alter their morphology to meet cellular demands epitomizes the ‘form follows function’ architectural principle. These remodeling events are collectively termed ‘mitochondrial dynamics’. The influence of mitochondrial dynamics and of the mitochondria-shaping proteins that control it on skeletal muscle physiology has become clearer. Endurance exercise prompts mitochondrial morphological changes that augment the respiratory capacity of the worked muscles. Mechanistically, exercise training increases mitochondrial fusion protein levels in skeletal muscle to promote the development of a hyperfused mitochondrial network that possesses denser cristae. Conversely, disruptions to the mitochondrial network through imbalances in mitochondrial dynamics lead to muscle atrophy. Insight into the connection between mitochondrial morphology and muscle-mass maintenance will help to pinpoint therapeutic targets that can be exploited to counteract sarcopenia and muscle atrophy in pathological conditions.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Current Opinion in Physiology
Current Opinion in Physiology Medicine-Physiology (medical)
CiteScore
5.80
自引率
0.00%
发文量
52
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信