氧稳态的系统生物学

IF 7.9 Q1 Medicine

Wiley Interdisciplinary Reviews-Systems Biology and Medicine Pub Date : 2017-02-21 DOI:10.1002/wsbm.1382

Debangshu Samanta, N. Prabhakar, G. Semenza

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引用次数: 45

摘要

后生动物物种通过缺氧诱导因子的活性维持氧气稳态，这些转录激活因子调节数百个基因的表达以匹配氧气供应和需求。在这里，我们回顾了缺氧诱导因子在细胞O2感知、O2传递、O2利用和全身O2感知的分子生理学和病理生理学中的作用。中国生物医学工程学报，2017,32(1):444 - 444。doi: 10.1002 / wsbm.1382

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Systems biology of oxygen homeostasis

Metazoan species maintain oxygen homeostasis through the activity of hypoxia‐inducible factors, which are transcriptional activators that regulate the expression of hundreds of genes to match O2 supply and demand. Here, we review the involvement of hypoxia‐inducible factors in the molecular physiology and pathophysiology of cellular O2 sensing, O2 delivery, O2 utilization, and systemic O2 sensing. WIREs Syst Biol Med 2017, 9:e1382. doi: 10.1002/wsbm.1382

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来源期刊

Wiley Interdisciplinary Reviews-Systems Biology and Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

18.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine